Abstract:

Objective To evaluate the value of autoantibodies combined with high resolution CT in predicting the invasion of lung adenocarcinoma in pure ground⁃glass nodule. Methods The surgical pathological biopsy of 101 cases of lung adenocarcinoma from Hubei Province′s third people′s hospital，and their chest high resolution CT revealed a single pure ground ⁃glass nodule. The patients were divided into two groups：preinvasive and invasive. The positive rate of autoantibodies and imaging signs in the two groups were observed and compared. Results There were no significant differences in lobulation ，Burr，vacuole sign ，air bronchus sign ，pleural indentation sign，and vascular bundle sign between preinvasive and invasive lesions（P > 0.05）. The diameter， average CT value and autoantibodies positive rate of invasive lesionswere significantly higher than those of preinva⁃ sive lesions，the differences were statistically significant（P < 0.05）. According to the receiver operating character⁃ istic curve，the best critical value of lesion diameter was 10.33 mm，and the mean CT value was⁃526.21 HU. To differentiate between preinvasive and invasive lesions，the sensitivity was 75.5 % and 92.5 %，respectively，the specificity was 89.6 % and 68.7 %，and the area under the curve was 0.888 and 0.737. The combined autoantibod⁃ ies′ sensitivity，specificity，and area under the curve were 92.5%，89.6%，and 0.956，respectively. Conclusion The size ，mean CT value ，and autoantibodies of a pure ground ⁃glass nodule can help to determine whether adenocarcinoma of the lung is invasive. When high resolution CT is combined with autoantibodies，it becomes more valuable.

Key words: lung adenocarcinoma,  , pure ground?glass nodule,  , autoantibodies,  , HRCT, invasion