Abstract:

Objective To investigate the relationship between internal carotid artery wall shear stress （WSS）and relapse in patients with acute ischemic cerebrovascular disease complicated by internal carotid athero⁃ sclerotic plaque. Methods Ninety ⁃ eight patients with atherosclerotic plaques in internal carotid artery who had been hospitalized in the Second Affiliated Hospital of Guangzhou Medical University from January 2018 to December 2020 were analyzed. The wall shear stress was calculated and the relapse was recorded during a follow ⁃up of two years. Results Left WSS（WSS⁃L），right WSS（WSS⁃R）and mean WSS（WSS⁃M）in the relapse group were higher than those in the control group（10.16 ± 5.02 vs. 7.82 ± 2.50，10.22 ± 2.09 vs. 7.82 ± 2.82，and 10.19 ± 3.16 vs. 7.82 ± 2.24）dyne/cm2 ，and the WBC count in the relapse group was higher than that in the control group （8.67 ± 1.67 vs. 6.35 ± 1.93）× 109 /L，the difference was statistically significant（P = 0.039，0.015，0.008，and 0.001）. Relapse was positively correlated with WSS⁃R（r = 0.372，P = 0.007），WSS⁃M（r = 0.305，P = 0.029）， and WBC count（r = 0.466，P = 0.001）. The predictive value of WSS ⁃M for relapse was analyzed by the ROC curve analysis. As WSS ⁃M was 7.95，the maximum sensitivity and specificity were 80% and 56%. Conclusions Internal carotid artery WSS is related to the relapse in the patients with acute ischemic cerebrovascular disease com⁃ plicated by atherosclerotic plaques.

Key words:

ischemic cerebrovascular disease,  , internal carotid artery,  , wall shear stress,  , relapse