Abstract: Vacuum sealing drainage is regarded as a revolutionary technology for the treatment of all kinds of wounds，especially for the acute and chronic complex wounds. This paper discussed and analyzed the principle，necessity，characteristics，advantages，latest progress，shortcomings and improvement measures of negative seal⁃ing drainage in maxillofacial region.

Key words: vacuum sealing drainage（VSD）, therapy of negative pressure wound（NPWT）, oral and , maxillofacial region, space infection, flap, osteomyelitis