Abstract:

Objective The study tried to investigate the predictive value of serum omentin⁃1（Omentin⁃1）， transforming growth factor ⁃ β1（TGF ⁃ β1）and ferritin（SF）levels of nonunion after thoracolumbar osteoporotic fracture internal fixation. Methods A total of 358 patients with thoracolumbar osteoporotic fractures were treated with vertebroplasty and internal fixation. Serum levels of Omentin⁃1，TGF⁃β1 and SF were measured before and 4 weeks after operation，the influencing factors of nonunion after internal fixation and predictive values of single and combined detection of the above indexes for postoperative bone nonunion were analyzed. Results The levels of serum Omentin⁃1 and TGF⁃β1 in all patients at 4 week after operation were higher than those before operation，and the serum SF level was lower than that before operation（P < 0.05）. After 6 months of follow⁃up，the incidence rate of bone nonunion was 5.59%. 4 weeks after operation，the serum Omentin ⁃1 and TGF ⁃β1 level in bone healing group were higher than those in bone nonunion group but the serum SF levels were lower than those in bone non⁃ union group（P < 0.05）. Blood supply damage，4 weeks after operation，serum Omentin⁃1，TGF⁃β1 and SF levels were the influencing factors of bone nonunion after internal fixation of thoracolumbar osteoporotic fractures（P < 0.05）. The receiver operating characteristic（ROC）curve results showed that the sensitivity and area under curve （AUC）of omentin⁃1，TGF⁃β1 and SF levels 4 weeks after surgery were higher than those of omentin⁃1，TGF⁃β1 and SF levels alone in predicting postoperative nonunion（P < 0.05）. Conclusion Serum levels of Omentin ⁃1， TGF⁃β1 and SF at 4 weeks after operation have good predictive value for bone nonunion after thoracolumbar osteo⁃ porotic fracture internal fixation but the combined predictive value is higher.

Key words: internal fixation of fracture,  , fracture union,  , serum omentin ?1,  , transforming growth factor?β1,  , ferritin