Abstract:

Objective To evaluate the effect of paclitaxel combined with carboplatin on left ventricular systolic function and motor synchrony in patients with ovarian cancer using two ⁃ dimensional speckle tracking imaging（2D⁃STI）technique. Methods A total of 30 patients with ovarian cancer were collected after surgery and received paclitaxel combined with carboplatin，and they were examined before chemotherapy，3⁃cycle，and 6⁃cycle， and 30 healthy subjects were selected forthe control group. After routine ultrasound examination，the layered strain technique was used to detect the longitudinal and circumferential strains of the whole left ventricle . The three layers of myocardium（GLS，GLS⁃endo，GLS⁃mid，GLS⁃epi，GCS，GCS⁃endo，CS⁃mid，CS⁃epi），the standard deviation of the time to peak（Tssl⁃SD，Tssc⁃SD）and the maximum difference（Tssl⁃dif，Tssc⁃dif）and the delay index （LSDI，CSDI）were obtained. The difference of parameters in each groupwere compared，and the ROC curve was used to evaluate the clinical value of various parameters in monitoring cardiac toxicity. The association between the parameters and the cumulative dose was analyzed. Results No significant difference was found between the pre⁃ chemotherapy group and the control group，while the conventional parameters（LVEDV，LVEF，e′）of the 3⁃cycle chemotherapy group and the 6⁃cycle chemotherapy group decreased，and the E/e′ value increased. The GLS，GLS⁃ endo，GLS⁃mid，GCS，GCS⁃endo，group were significantly reduced（P < 0.05），with a decreasing trend. At the same time，GLS⁃epi and GCS⁃epi decreased during 6⁃cycle of chemotherapy. The delay of Tssl ⁃ SD and LSDI in the 3⁃cycle chemotherapy group， while the delay of Tssl⁃SD in the 6⁃cycle chemotherapy group was more obvious. The ROC curve showed that AUC （0.922）and specificity（90.00%）of GLS⁃endo were the highest，the GLS sensitivity was the highest（86.67%）， GLS⁃endo was negatively correlated with drug dose（r = -0.732，P < 0.01）. Conclusion 2D⁃STI technique should be used in the early assessment of paclitaxel combined with carboplatin on left ventricular systolic function and 

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