Abstract:

Chimeric antigen receptor（CAR）T cell therapy faces many challenges in the treatment of solid tumors due to the immunosuppressive microenvironment and the heterogeneity of antigen expression. With the devel⁃ opment of molecular biology，molecule⁃targeted drugs with high efficiency and low toxicity have become a research hotspot in therapies for tumors. CAR⁃T cell combined molecule⁃targeted therapies shows an inspiring prospect. This paper reviews the current status and research progress of CAR⁃T cell combined molecule⁃targeted drugs for solid tu⁃ mors，discusses the key basic principles，potential roles，future prospects and challenges of CAR⁃T cells com⁃ bined with those drugs with different mechanisms targeting cytoplasm，nucleus，or extracellular environment in the treatment of solid tumors. It aims at exploring the benefit of this combination therapy for more cancer patients and provides support for subsequent clinical research.

Key words: CAR?T cells,  , combination therapy,  , tumor immunity,  , molecule? targeted drugs