LncRNA及miRNA对NLRP3炎症小体信号的调控机制及其在相关疾病中的意义

doi:10.3969/j.issn.1006⁃5725.2020.22.024

Abstract

Abstract:

The NLRP3 inflammasome is an immportant component of the innate immune system thatmediates caspase⁃1 activation and the secretion of pro⁃inflammatory cytokines IL⁃1β/IL⁃8. However，the aberrantactivation of the NLRP3 inflammasome has been linked with several diseases，such as parkinson disease，athero⁃sclerosis，acute lung injury and etc. Non⁃coding RNAs，such as miRNA and lncRNA，refer to RNAs which cannot code for proteins but can regulate the expression of NLRP3 at transcription or post⁃transcription level and partic⁃ipate in the progress of diverse NLRP3⁃related diseases. In this review，the latest developments in this area will beelucidated to provide new insights for further treatment of NLRP3⁃related diseases.

Key words: non?coding RNA, lncRNA, miRNA, NLRP3 inflammasome

LU Jiawei, LIU Xiaogu, ZHANG Wenbo. The regulatory mechanism of lncRNA and miRNA on NLRP3 inflammasome signal and non⁃coding RNA′s role in associated diseases[J]. The Journal of Practical Medicine, 2020, 36(22): 3149-3152.

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The regulatory mechanism of lncRNA and miRNA on NLRP3 inflammasome signal and non⁃coding RNA′s role in associated diseases

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