The Journal of Practical Medicine ›› 2024, Vol. 40 ›› Issue (19): 2672-2677.doi: 10.3969/j.issn.1006-5725.2024.19.002
• Basic Research • Previous Articles Next Articles
Yangyang CHEN1,Hongqi MA2,Jing YANG1,Zongyue WU1,Ping. ZHU1
Received:
2023-09-26
Online:
2024-10-10
Published:
2024-10-22
CLC Number:
Yangyang CHEN,Hongqi MA,Jing YANG,Zongyue WU,Ping. ZHU. Impact of Atractylodin on lung tissue damage in young asthma rats by regulating the CXCL12/CXCR4 signaling pathway[J]. The Journal of Practical Medicine, 2024, 40(19): 2672-2677.
Tab.2
Comparison of serum cytokine levels in all groups"
组别 | IL-13 | IL-4 | IL-5 | IL-17 |
---|---|---|---|---|
CON组 | 11.79 ± 2.58 | 16.53 ± 1.69 | 26.43 ± 1.76 | 36.90 ± 4.23 |
Model组 | 54.87 ± 6.46* | 48.58 ± 5.24* | 65.32 ± 5.88* | 68.56 ± 8.78* |
苍术素组 | 22.12 ± 3.35△ | 24.35 ± 2.59△ | 31.54 ± 2.76△ | 43.09 ± 6.98△ |
CXCL-12组 | 84.54 ± 9.34△ | 65.85 ± 7.37△ | 97.64 ± 8.12△ | 96.54 ± 15.43△ |
苍术素+CXCL-12组 | 43.67 ± 4.64▲ | 43.36 ± 4.45▲ | 52.46 ± 3.45▲ | 56.23 ± 8.34▲ |
F值 | 145.931 | 104.498 | 200.844 | 37.253 |
P值 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Tab.3
Comparison of cytokine levels in BALF among all groups"
组别 | IL-13 | IL-4 | IL-5 | IL-17 |
---|---|---|---|---|
CON组 | 10.23 ± 2.70 | 15.69 ± 1.68 | 21.38 ± 3.27 | 41.79 ± 4.75 |
Model组 | 49.54 ± 6.50* | 43.93 ± 4.26* | 52.38 ± 6.37* | 64.87 ± 5.56* |
苍术素组 | 18.58 ± 3.35△ | 22.47 ± 2.53△ | 30.28 ± 3.87△ | 42.12 ± 3.77△ |
CXCL-12组 | 69.29 ± 9.37△ | 61.49 ± 8.63△ | 85.53 ± 9.39△ | 84.12 ± 7.34△ |
苍术素+CXCL-12组 | 41.58 ± 4.38▲ | 39.38 ± 2.48▲ | 48.56 ± 5.09▲ | 63.67 ± 6.12▲ |
F值 | 101.639 | 91.519 | 101.895 | 59.800 |
P值 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Tab.6
Effects of atractylotin on CXCL12/CXCR4 signaling pathway protein levels in rats"
组别 | CXCL12/GAPDH | CXCR4/GAPDH |
---|---|---|
CON组 | 0.33 ± 0.02 | 0.22 ± 0.02 |
Model组 | 0.65 ± 0.07* | 0.75 ± 0.09* |
苍术素组 | 0.42 ± 0.05△ | 0.31 ± 0.02△ |
CXCL-12组 | 0.93 ± 0.07△ | 0.91 ± 0.08△ |
苍术素+CXCL-12组 | 0.58 ± 0.06▲ | 0.69 ± 0.07▲ |
F值 | 99.147 | 130.812 |
P值 | < 0.001 | < 0.001 |
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