肥大细胞来源的外泌体在支气管哮喘中的研究进展

doi:10.3969/j.issn.1006-5725.2024.15.026

Abstract

Abstract:

Carrying the pan-mast cell markers IgE immunoglobulin high-affinity receptor （FcεRI） and SCF receptor c-kit， mast cell-derived exosomes are rich in sphingomyelin， lipid-associated proteins， and loaded with MHC-II molecules and transfer functional mRNAs and miRNAs to the receptor of CD34⁺ progenitor cells and mast cells. Activated mast cell-derived exosomes contain a large number of functional mast cell-specific mediators and may vary in size， protein， lipid， RNA and DNA contents. Mast cell exosomes can recruit B cells and T cells to the lungs， regulating immune and inducing the activation of other asthma-related cells. Also， mast cell-derived exosomes interact with airway smooth muscle cells and induce the release of pro-inflammatory cytokines， allowing asthma symptoms to persist. Immune complexes （IgE and antigens） present on mast cell-derived exosomes exacerbate local allergic reactions by a self-amplification mechanism meanwhile deliver antigens to other immune cells. Mast cell-derived exosomes may be potential targets for the treatment of bronchial asthma， and their purification and optimization be needed further to research. This article will review the mechanism of mast cell-derived exosomes in bronchial asthma， so as to provide new ideas for the prevention and treatment of bronchial asthma.

Key words: exosomes, mast cells, bronchial asthma

CLC Number:

R562.2⁺5

Jiao XU,Min ZHANG,Guogang. XIE. Research progress of mast cell⁃derived exosomes in bronchial asthma[J]. The Journal of Practical Medicine, 2024, 40(15): 2194-2198.

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Research progress of mast cell⁃derived exosomes in bronchial asthma

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