树突状细胞在过敏性哮喘发病中的作用及机制研究新进展

doi:10.3969/j.issn.1006-5725.2023.17.023

Abstract

Abstract:

Allergic asthma is a chronic inflammatory airway disease characterized by over-activation of T helper 2 （Th2） cells in response to harmless air allergens. With high incidence and relapse rates， allergic asthma severely affects the life quality of patients. Dendritic cell （DC） plays important roles in initiating and maintaining Th2-mediated immune response during allergic asthma development，but the mechanism remains unclear. Therefore， it is important to study the function and underlying mechanism of DC in the pathogenesis of allergic asthma. We summarize the latest progress of immunometabolism， cytokines， and epigenetics in regulating DC function and DC-mediated Th2 immune responses， to direct the pathogenesis of allergic asthma. Further understanding the mechanisms by which DC regulates allergic asthma will provide new strategies for the treatment of allergic asthma.

Key words: dendritic cell, allergic asthma, immunoregulation

CLC Number:

R562.2+5

Yunman ZHANG,Gonghua HUANG,Yanyan. WANG. Research progress in the regulation of allergic asthma by dendritic cells[J]. The Journal of Practical Medicine, 2023, 39(17): 2280-2284.

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Research progress in the regulation of allergic asthma by dendritic cells

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