定量CT评价胸椎骨密度及与年龄相关的骨丢失

doi:10.3969/j.issn.1006-5725.2024.10.017

Abstract

Abstract:

Objective To compare the bone mineral density and age?related bone loss rate of thoracic and lumbar vertebrae using quantitative CT（QCT）， and to explore the feasibility of measuring bone density and bone loss rate using thoracic QCT. Methods A total of 708 patients who underwent full abdominal CT scans due to trauma， acute abdominal disease， and health examination from March 2022 to March 2023 were selected. The average BMD of T10 to L3 vertebral bodies were measured using quantitative CT software. The subjects were divided into several age groups according to the age of every 10 years. The average bone density and the age?related annual rate of bone density loss of the thoracic and lumbar vertebrae for each group were computed， the correlation analysis between thoracic and lumbar BMD and age was conducted using Pearson correlation analysis. Results The peak BMD for both males and females was in the 20 to 29 years age group. After the age of 30， the bone density of the thoracic and lumbar vertebrae began to decrease to varying degrees. For females aged 80 to 89， the cumulative bone loss rate for the thoracic and lumbar vertebrae was 60.61% and 61.34%， respectively， while for males， it was 44.45% and 49.35%， respectively. The BMD of the thoracic and lumbar vertebrae in both males and females showed a negative correlation with age （P < 0.01）. There was a significant positive correlation between the bone mineral density of the thoracic and lumbar vertebrae （for males， r = 0.96； for females， r = 0.98； P < 0.01）. Conclusion Both thoracic and lumbar QCT accurately displayed BMD and bone loss in different age groups， and thoracic QCT could be used as a method for evaluating and monitoring bone loss.

Key words: bone loss, bone mineral density, tomography， X?ray computed, quantitative CT, thoracic vertebrae

CLC Number:

R816

Junlu ZHAO,Zhai LIU,Deyuan ZHAO,Guanwei NIE,Qingyun. REN. Quantitative CT evaluation for thoracic vertebral bone density and age⁃related bone loss[J]. The Journal of Practical Medicine, 2024, 40(10): 1429-1433.

Figures/Tables 6

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References 21

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年龄段	例数	胸椎			腰椎
年龄段	例数	BMD（mg/cm³）	较上一年龄组骨丢失（%）	累计骨丢失率（%）	BMD（mg/cm³）	较上一年龄组骨丢失（%）	累计骨丢失率（%）
20～29岁	13	175.40 ± 23.10	-	-	157.33 ± 22.43^△	-	-
30～39岁	49	163.17 ± 26.91	-6.97	-6.97	149.68 ± 27.11 ^△	-4.86	-4.86
40～49岁	59	147.31 ± 25.21	-9.72	-16.01	130.66 ± 23.84^*△	-12.71	-16.95
50～59岁	81	138.34 ± 27.25	-6.09	-21.13	119.91 ± 27.43^△	-8.23	-23.78
60～69岁	65	109.44 ± 25.98^*	-20.89	-37.61	93.05 ± 25.34^*△	-22.40	-40.86
70～79岁	62	104.86 ± 26.99	-4.18	-40.22	87.37 ± 25.86 ^△	-6.10	-44.47
80～89岁	22	97.44 ± 22.65	-7.08	-44.45	79.69 ± 21.10 ^△	-8.79	-49.35

年龄段	例数	胸椎			腰椎
年龄段	例数	BMD（mg/cm³）	较上一年龄组骨丢失（%）	累计骨丢失率（%）	BMD（mg/cm³）	较上一年龄组骨丢失（%）	累计骨丢失率（%）
20～29岁	13	197.03 ± 27.29	-	-	188.96 ± 26.05^△	-	-
30～39岁	34	190.21 ± 29.74	-3.46	-3.46	182.30 ± 31.35^△	3.52	-3.52
40～49岁	55	168.40 ± 31.37^*	-11.47	-14.53	158.65 ± 26.01^*△	-12.97	-16.04
50～59岁	80	125.71 ± 32.61^*	-25.35	-36.20	117.38 ± 33.84^*△	-26.01	-37.88
60～69岁	102	97.09 ± 30.54^*	-22.77	-50.72	92.80 ± 33.51^*△	-20.94	-50.89
70～79岁	54	82.49 ± 25.54^*	-15.04	-58.13	77.61 ± 29.36^*△	-16.37	-58.93
80～89岁	19	77.61 ± 31.03	-5.92	-60.61	73.05 ± 8.35^△	-5.88	-61.34

		胸椎BMD		腰椎BMD
		男	女	男	女
年龄	r值	-0.721	-0.776	-0.720	-0.791
	P值	0.000	0.000	0.000	0.000
BMI	r值	0.232	0.176	0.227	0.154
	P值	0.001	0.015	0.001	0.034

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Quantitative CT evaluation for thoracic vertebral bone density and age⁃related bone loss

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