Abstract:

Objective To analyze the bone mineral density of lumbar spine QCT and spinal fragility fractures in middle⁃aged and elderly people in Guizhou province. Methods A total of 2，380 middle⁃aged and elderly patients over 50 who underwent QCT bone mineral density examination in our hospital were enrolled. The QCT bone mineral density value was analyzed，and the correlation between QCT bone mineral density and spinal fragility fracture was analyzed by sex，age and group. Results The proportion of normal bone mass，osteopenia， osteoporosis and severe osteoporosis was 80.00% ，16.26% ，2.82% and 0.92% ，respectively. The incidence of osteoporosis was 3.74%，8.17% in females and 2.52% in males，respectively，which was significantly higher in females than in males（χ2 = 35.769，P < 0.001）. The proportion of low bone mass was 16.26%，21.40% in females， and 14.84% in males，respectively，showing statistical significance（χ2 = 12.721，P < 0.001）. With the increase of age，the bone mineral density of the population over 60 decreased，and the prevalence of osteoporosis gradually increased，especially in women，with statistical significance（P < 0.05）. The prevalence of bone mass loss in men and women aged 50 ~ 59 years，60 ~ 69 years and 70 ~ 79 years increased gradually with the increase of age，especially in women（P < 0.05）. There were 42 cases（1.76%）of spinal fragility fractures，including 31 males and 11 females， showing no significant difference（P > 0.05）. The incidence of fracture in patients with osteoporosis（14.61%） was significantly higher than that in patients without osteoporosis（1.27%），and the difference was statistically significant（P < 0.001）. Bone mineral density with and without spinal fragility fracture were（99.40 ± 41.78）mg/cm3 and（141.98 ± 30.56）mg/cm3 ，respectively，and the difference was statistically significant（P < 0.001）. The bonemineral density of the middle aged and the elderly in different age groups was significantly lower than that of the same age group without spinal fragility fracture（P < 0.05）. Conclusion QCT bone mineral density of lumbar spine can accurately reflect vertebral bone mass，and provide a quantitative basis for the prediction and prevention of osteoporosis and spinal fragility fractures in the middle⁃aged and elderly.

Key words:

Guizhou province, middle ?aged and elderly people, quantitative CT, bone mineral density, fragility fracture of spine