Abstract:

Objective To investigate and analyze the molecular typing，clinicopathological characteristics and prognosis of breast cancer patients from different regions and nationalities in Guangxi Zhuang Autonomous Region. Methods A total of 1，586 cases with stage Ⅰ⁃Ⅲ breast cancer who were treated in Guangxi Medical University Cancer Hospital from January 1，2015 to December 31，2018 were included in the study. The clinical and pathological characteristics and the relationship with prognosis of four subtype were compared and analyzed. Results The rates of luminal A，luminal B，HER⁃2 overexpression，and triple negative were 14.9%，55.0%，17.7%， and 12.4%，respectively. There were significant differences in age of onset，tumor stage，tumor size，pathological type and number of lymph node metastasis between the groups（all P < 0.05）. Cox analysis showed that molecular typing，tumor size and number of lymph node metastasis were the independent prognostic factors for OS，while molecular typing，lymph node metastasis was the independent prognostic factor for DFS. Subgroup analysis showed that the OS rate of Zhuang nationality was significantly lower than that of Han nationality（5⁃year OS rate：94% vs. 97.8%，χ2 = 4.623，P = 0.032）. The OS rete of the population living in Southern and Western Guangxi was significantly higher than that living in Nanning，Eastern and Northern Guangxi（χ2 = 16.012，P = 0.007）. Conclusions The prognosis of breast cancer is related to molecular typing，tumor size，pathological type，lymph node metastasis and other characteristics. There is no significant difference in the classification characteristics of breast cancer in popula⁃ tion from different regions and nationalities in Guangxi，but the differences in lifestyle and economic status of differ⁃ ent regions and nationalities have a certain impact on the prognosis of some types of breast cancer.

Key words:

breast cancer, molecular typing, Guangxi, prognosis