Abstract:

Objective To analyze the content of circulating tumor cells（CTCs）in autologous blood recov⁃ ered during brain tumor resection and the effect of autologous blood transfusion on prognosis，to evaluate the safety of autologous blood recovery combined with leukocyte filter in brain tumor resection in children. Methods The content of CTCs in children undergoing brain tumor resection before and after autologous blood transfusion was analyzed，and the effect of leukocyte filter on removing circulating tumor cells was evaluated. The intraoperative blood loss，blood transfusion and prognosis of children in autologous blood transfusion group and allogeneic blood transfusion group were compared. The effect of autologous blood transfusion on postoperative recovery was analyzed. Results There was no significant difference in the content of CTCs in autologous blood transfusion group before and after the operation（P > 0.05）. The operation and anesthesia time of the autologous blood transfusion group were longer and the amount of intraoperative bleeding was more when compared with the allogeneic blood transfu⁃ sion group（P < 0.05），but there was no significant difference in the amount of allogeneic red blood cell，plasma and cold precipitation between the two groups（P > 0.05）. There was no significant difference between the two groups in terms of postoperative complications，duration of postoperative mechanical ventilation，postoperative hospital stay and postoperative recurrence rate（P > 0.05）. Conclusion The application of autologous blood recovery combined with leukocyte filter in pediatric brain tumor resection has no effect on postoperative tumor recurrence and prognosis，and it can be safely applied in clinical practice.

Key words:

children, tumor, autologous blood salvage, leukocyte filter, prognosis