Abstract:

Objective To study and analyze the value of whole ⁃ body bone scanning（WBS）combined with target/non⁃target ratio（T/NT）in the diagnosis of bone metastases. Methods A total of 157 patients with sus⁃ pected bone metastases admitted to our hospital from January 2，2019 to November 25，2020 were included in this study. WBS were performed on all subjects，and T/NT was measured and calculated using a GE post ⁃ processing software system. The results of pathological diagnosis were used as the gold standard to analyze the efficacy of differ⁃ ent examination methods in the diagnosis of bone metastases. In addition，the differences of T/NT in different bone metastases were compared. Results The results of pathological diagnosis showed that there were 75 cases of bone metastases and 82 cases of benign lesions among 157 suspected patients with bone metastases. The T/NT of patients with bone metastases was（12.40 ± 3.15），which was significantly higher than that of patients with benign lesions （6.69 ± 2.01），and the difference was statistically significant（P < 0.05）. The sensitivity，specificity and accuracy of WBS combined with T/NT in the diagnosis of bone metastases were 93.33%，95.12% and 94.27% respectively， according to the pathological diagnosis results as the gold standard. All of them were higher than those of WBS （81.33%，85.37%，83.44%）and T/NT（68.00%，81.71%，75.16%）. The difference was statistically significant （all P < 0.05）. T/NT of bone metastases from ribs was lower than that of bone metastases from pelvis，spine and other sites，and T/NT of bone metastases from pelvis was lower than that of bone metastases from spine and other sites（all P < 0.05）. Conclusion WBS combined with T/NT has high sensitivity and specificity in the diagnosis of bone metastases. 

Key words: bone metastases,  , full?body bone scan,  , target/non?target ratio,  , diagnostic value