The Journal of Practical Medicine ›› 2021, Vol. 37 ›› Issue (6): 705-708.doi: 10.3969/j.issn.1006⁃5725.2021.06.002

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Advances in pathogenesis and novel biomarkers of sepsis associated acute kidney injury

KANG Lingkai*， LI Xiaoyue，ZHANG Qian.   

  1. Department of Emergency，Affiliated Hospital of Guilin Medical College，Guangxi 541001，China

  • Online:2021-03-25 Published:2021-03-25
  • Contact: LI Xiaoyue E⁃mail：euyeuy1983@126.com

Abstract:

Sepsis is one of the main causes of death in patients with acute and critical illness. Acute kidney injury（SA ⁃AKI）is associated with poor prognosis in sepsis patients，which is complex pathogenesis and currently believed to be mainly related to immune inflammatory response，coagulation cascade activation，renal cell apoptosis，and mitochondrial kinetics abnormities. Early diagnosis and treatment of SA ⁃AKI patients can reduce the mortality. Previous diagnostic criteria based on serum creatinine have limitations. Recent studies have found that a variety of novel biomarkers are involved in the occurrence and development of SA⁃AKI，which may be new targets for the early diagnosis and treatment of SA ⁃AKI. In this brief reviewed paper，the pathophysiological mechanism of SA⁃AKI and its related novel biomarkers are discussed.

Key words:

sepsis associated acute kidney injury, mechanism, biomarker