Abstract:

Objective To investigate the effects of IABP in combination with rhBNP in patients undergo⁃ ing emergency percutaneous coronary intervention（PCI）for acute anterior myocardial infarction. Methods The study included 91 patients who had an acute anterior myocardial infarction and needed emergency PCI. They were divided into three groups based on the application of IABP and rhBNP：group A received IABP combined with rhBNP，group B received IABP，and group C received rhBNP. Cardiac function index，average length of stay， adverse events during hospitalization and post⁃discharge follow⁃up were all examined. Results （1）the peak NT⁃proBNP concentration in group A was lower than that in group B and C（P < 0.05）.（2）There were no significant differences in LVDD or LVEF among the three groups at admission（P > 0.05）. During the follow ⁃up，LVDD in group A was smaller than that in group B and group C（P < 0.05）. In addition，compared with baseline，the LVDD decreased and LVEF increased in group A at 6 months after discharge（P < 0.05）. However，there were no statistical differences in LVDD and LVEF between groups B and C when compared to baseline（P > 0.05）.（3）During hospital⁃ ization，the average length of stay and adverse events did not differ statistically（P > 0.05）.（4）During the follow⁃up period，the incidence of heart failure requiring hospitalization was 2.17% in group A，17.86% in group B，and5.88% in group C，and the difference was statistically significant（P < 0.05）. However，there was no significant difference in revascularization among the three groups（P > 0.05）. Conclusion The combination of IABP and rhBNP can improve cardiac function and reduce the incidence of heart failure requiring hospitalization after dis⁃ charge in patients with acute anterior STEMI undergoing emergency PCI.

Key words:

text-indent:0pt, "> sssacute st?segment elevation myocardial infarction,  , emergency percutaneous coronary inter? vention,  , intra?aortic balloon counterpulsation,  , recombinant human brain natriuretic peptide