Abstract:

Objective To investigate whether Luo′s Endometriosis Formula and combined oral contracep⁃ tives are equally effective in postoperative maintenance treatment for patients with ovarian endometriomas. Methods A total of 106 cases with stage Ⅲ ovarian endometriomas were enrolled in this study，including 56 patients in the combined oral contraceptive group and 50 patients in the Luo′s Endometriosis Formula group. Carbohydrate antigen 125（CA⁃125），visual analog scale（VAS）scores and antimullerin hormone（AMH）were monitored before surgery，2 months after surgery，4 months after surgery and 6 months after surgery，respectively. The recurrence rate at 6 months after surgery was calculated，and statistical analysis was performed for each observation index between the two groups. Results Six months after surgery，there was no statistical difference in the overall trend of postoperative CA⁃125，VAS score，and AMH between the Luo′s Endometriosis Formula group and the combined oral contraceptive group（P > 0.10）. Six months after surgery，there was no significant difference in recurrence rate between the two groups（P = 0.908）. The combined oral contraceptive group′s CA⁃125 decline rate was faster than the Luo′s Endometriosis Formula group′s in the first two months after surgery，but there was no statistical difference six months later. Other indexes′ postoperative decline rates did not differ significantly between the two groups. There were no serious adverse reactions in either group. Conclusions Luo′s Endometriosis Formula has the same curative effect and clinical application value as combined oral contraceptives in the maintenance treatment of ovarian endometriomas 6 months after cystectomy.

Key words: Luo′ s Endometriosis Formula,  , combined oral contraceptive,  , ovarian endometrioma,  , maintenance treatment