The Journal of Practical Medicine ›› 2021, Vol. 37 ›› Issue (5): 596-600.doi: 10.3969/j.issn.1006⁃5725.2021.05.008

• Basic Research • Previous Articles     Next Articles

Inhibitive effect of propofol on proliferation，migration and invasion of ovarian cancer SKOV3 cells in vitro by down⁃regulating expression of yes⁃associated protein

BAI Xiaozhi，XIE Xiaojuan，YUAN Xiang， LIU Yiwen，KONG Jinyu，SUN Wei，LI Yanle.   

  1. Clinical Medical Collage of He′nan University of Science and Tech⁃ nology；*Department of Anesthesiology，Kaiyuan Branch of the First Affiliated Hospital of He′nan University of Sci⁃ ence and Technology，Luoyang 471003，China

  • Online:2021-03-10 Published:2021-03-10
  • Contact: XIE Xiaojuan E⁃mail：13693818030@163.com

Abstract:

Objective To investigate the effects of propofol on the proliferation，migration and invasion of ovarian cancer SKOV3 cells. Methods SKOV3 cells were divided into blank control group，solvent control group，25 μmol/L propofol group，50 μmol/L propofol group and 100 μmol/L propofol group. Immunofluorescence assay and Western blot were used to detect the effect of propofol on the expression of yes associated protein（Yap） in SKOV3 cells. Whether Yap over⁃expression interfered with the inhibitory effect of propofol on proliferation ， migration and invasion of SKOV3 cells was observed. Results Propofol inhibited the proliferation，migration and invasion of ovarian cancer SKOV3 cells；Propofol down regulated the expression of Yap protein in the nucleus of SKOV3 cells and Yap overexpression interfered with the inhibitory effect of propofol on the proliferation，migration and invasion of SKOV3 cells. Conclusion propofol may inhibit the proliferation，migration and invasion of SKOV3 cells by down regulating the expression of Yap protein.

Key words:

text-indent:0pt, "> propofol, ovarian cancer, Hippo signaling pathway, yes?associated protein, prolifera?tion, migration, invasion