STT3A和STT3B在上皮性卵巢癌中的表达及与预后的关系

doi:10.3969/j.issn.1006-5725.2023.16.009

Abstract

Abstract:

Objective To explore the relationship between the expression levels of STT3A and STT3B in Epithelial Ovarian Cancer （EOC） and the clinicopathological features and prognosis of the patients. Methods The clinical information of 88 patients with EOC who underwent surgical treatment and 22 patients with normal tubal epithelium and normal ovarian tissue in our department from 2010 to 2019 were collected and followed up. The expressions of STT3A and STT3B in EOC and control groups were detected by immunohistochemistry， and their relationships with clinicopathological features and prognosis of patients were analyzed. Results The expression of STT3A and STT3B in EOC patients was significantly higher than that of control group （P < 0.05）， and the expression of STT3A was related to tumor differentiation degree and lymph node metastasis （P < 0.05）. The expression of STT3B was significantly correlated with FIGO staging， serum CA125 level， Lymph?vascular space invasion， degree of tumor differentiation and lymph node metastasis （P < 0.05）. Kaplan?Meier survival analysis showed that the higher expressions of STT3A and STT3B were associated with poor prognosis （P < 0.05）. Multivariate Cox regression analysis revealed that the high expressions of STT3A and STT3B were independent risk factors for the prognosis of EOC patients （P < 0.05）. Western Blot results showed that STT3A and STT3B were significantly expressed in ovarian cancer （P < 0.05）. Conclusion STT3A and STT3B are extremely expressed in EOC tissues and are associated with poor prognosis of EOC patients， and may be potential markers for the prognosis of EOC patients.

Key words: epithelial ovarian cancer, STT3A, STT3B, clinicopathological features, prognosis

CLC Number:

R737.31

Chongfeng SUN,Ping YANG,Jishuai HOU,Zouyu ZHAO,Panpan. YU. Expression and prognosis of STT3A and STT3B in epithelial ovarian cancer[J]. The Journal of Practical Medicine, 2023, 39(16): 2062-2070.

Figures/Tables 12

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References 16

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患者临床病理信息	例数	构成比（%）	患者临床病理信息	例数	构成比（%）
诊断时年龄			肿瘤分化程度
< 55岁	56	63.64	低分化	54	61.4
≥ 55岁	32	36.36	中分化	6	6.8
FIGO分期			高分化	28	31.8
Ⅰ期	26	29.55	淋巴脉管间隙浸润
Ⅱ期	13	14.77	无	62	70.45
Ⅲ期	48	54.55	有	26	29.55
Ⅳ期	1	1.13	淋巴结转移
组织学类型			无	64	72.73
浆液性癌	58	65.91	有	24	27.27
黏液性癌	17	19.32	CA125 （U/mL）
子宫内膜样癌	4	4.54	< 200	49	55.69
透明细胞癌	9	10.23	≥ 200	39	44.31

组织类型	例数	STT3A		STT3B
组织类型	例数	低表达	高表达	低表达	高表达
正常输卵管上皮	22	20	2	21	1
高级别浆液性癌	42	11	31	13	29
χ²值		24.212		24.121
P值		< 0.001		< 0.001

组织类型	例数	STT3A		STT3B
组织类型	例数	低表达	高表达	低表达	高表达
正常卵巢	22	18	4	20	2
非高级别浆液性癌	46	20	26	22	24
χ²值		8.873		11.697
P值		0.003		0.001

临床病理特征	STT3A（n = 88）		STT3B（n = 88）
临床病理特征	低表达	高表达	低表达	高表达
年龄
≥ 55岁	10	22	12	20
< 55岁	21	35	23	33
χ²值	0.349		0.108
P值	0.555		0.742
FIGO分期
Ⅰ-Ⅱ期	16	23	20	19
Ⅲ-Ⅳ期	15	34	15	34
χ²值	1.032		3.873
P值	0.310		0.049
组织学类型
浆液性	19	39	23	35
其他^*	12	18	12	18
χ²值	0.454		0.001
P值	0.500		0.975
分化程度
低分化	13	41	16	38
中高分化	18	16	19	15
χ²值	7.619		6.003
P值	0.006		0.014
CA125
≥ 200 U/mL	13	26	8	31
< 200 U/mL	18	31	27	22
χ²值	0.110		10.846
P值	0.740		0.001
淋巴脉管间隙浸润
是	6	18	5	19
否	25	39	30	34
χ²值	1.513		4.942
P值	0.219		0.026
淋巴结转移
是	3	21	6	20
否	26	36	29	33
χ²值	4.139		4.294
P值	0.042		0.038

因素	单因素分析			多因素分析
因素	HR	95% CI	P值	HR	95% CI	P值
年龄（< 55岁 vs. ≥ 55岁）	2.066	1.079～3.956	0.029	2.067	1.063～4.302	0.032
FIGO分期（Ⅰ-Ⅱ期 vs. Ⅲ-Ⅳ期）	2.696	1.301～5.687	0.008	1.931	0.888～4.199	0.097
组织类型（浆液性 vs. 其他^*）	0.718	0.347～1.483	0.370
分化程度（中高 vs. 低）	4.717	1.928～11.542	0.001	2.922	1.126～7.584	0.028
CA125（< 200 U/mL vs. ≥ 200 U/mL）	1.093	0.572～2.089	0.787
淋巴脉管间隙浸润（否 vs. 是）	1.948	0.998～3.803	0.051
淋巴结转移（否 vs. 是）	1.858	0.943～3.663	0.073
STT3A （低 vs. 高）	3.219	1.483～6.987	0.003	2.259	1.000～5.103	0.05
STT3B （低 vs. 高）	3.511	1.579～7.808	0.002	2.435	1.033～5.743	0.042

Expression and prognosis of STT3A and STT3B in epithelial ovarian cancer

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