Abstract:

Necroptosis is a major discovery in the field of cell death in recent decades. At present， in the field of ophthalmology， the activation of necroptosis pathway has been found from corneal diseases， glaucoma， retinal diseases and so on. In addition to Necrostatin-1（Nec-1）， a necroptosis inhibitor targeting receptor-interacting protein1（RIP1）， drugs such as GSK2399872A（GSK872）， a receptor-interacting protein3（RIP3） inhibitor， and TC13172， a novel inhibitor targeting mixed lineage kinase domain-like protein （MLKL）， have made major breakthroughs in cell death mechanisms. Currently in the field of ophthalmology， necroptosis inhibitors have demonstrated their protective effects in a variety of disease models. This article focuses on the molecular mechanism of necroptosis and the research results of its inhibitors in ophthalmology， discusses the potential of necroptosis as a new target for the treatment of ophthalmic diseases， and puts forward suggestions for its further research in the field of ophthalmology.

Key words: cell death, necroptosis, receptor-interacting protein1/3, mixed lineage kinase domain-like protein, Necrostatin-1, cornea, glaucoma, retina