Abstract:

Colorectal cancer is one of the most common gastrointestinal malignancies. With the develop⁃ ment of diagnosis and treatment，the mortality has decreased，but the prognosis is still poor. At present，chemo⁃ therapy drugs used to treat colorectal cancer generally inhibit tumor growth by inducing cell death 。 However，cell death resistance is the main reason for the unsuccessful treatment and recurrence of gastrointestinal tumors，and most tumor cells are drug⁃resistant due to the dysregulation of apoptotic mechanism. New cell death modes such as necroptosis may offer the possibility for colorectal cancer treatment. Necroptosis is a caspase ⁃independent cellular pattern，usually characterized by necrotic morphology，mainly regulated by RIPK 1 and RIPK 3，and performed by MLKL. Currently，researches on targeted therapy for colorectal cancer based on necroptosis are ongoing，suggest⁃ ing that necroptosis will provide a new strategy for the treatment of colorectal cancer. This review focuses on necrop⁃ tosis and discusses its mechanism of action in the development and treatment of colorectal cancer.

Key words:

colorectal cancer, necroptosis, receptor interacting serine/threonine ? protein kinase 1/3 （RIPK1/RIPK3）, mixed lineage kinase domain?like protein（MLKL）