The Journal of Practical Medicine ›› 2023, Vol. 39 ›› Issue (17): 2277-2279.doi: 10.3969/j.issn.1006-5725.2023.17.022

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Research progress on relationship between cardiac amyloidosis and atrial fibrillation and its pathogenesis

Bo WU1,2,Hengli LAI2(),Guowang SHEN1,2,Zhenhuan CHEN2,Yuan. LIU1,2   

  1. *.Nanchang University Medical College,Nanchang 330000,China
    *.Jiangxi Provincial People′s Hospital,the First Affiliated Hospital of Nanchang Medical college,Nanchang 330000,China
  • Received:2023-06-13 Online:2023-09-10 Published:2023-09-27
  • Contact: Hengli LAI E-mail:Laihengli@ 163.com;Laihengli@163.com

Abstract:

Cardiac amyloidosis (CA) is a myocardial disease caused by extracellular deposition of misfolded amyloid proteins in the myocardium. CA is associated with a higher prevalence of atrial fibrillation (AF), and myocardial amyloid infiltration can contribute to atrial electrical and structural remodeling through hemodynamic changes, increased ventricular wall stress, atrial amyloid deposition, and autonomic dysfunction, leading to the development and progression of AF. At present, the mechanism of CA in the pathogenesis of AF has not been elucidated. Therefore, exploring the relationship between CA and AF and the possible pathogenesis will help to deepen the knowledge of such patients and provide reference for clinical prevention and treatment.

Key words: cardiac amyloidosis, atrial fibrillation

CLC Number: