Abstract:

Objective To objectively evaluate the effect of anti vascular endothelial growth factor （VEGF）therapy combined withdifferentiation and treatment from dampness on the morphology of macular edema in retinal vein occlusion（RVO）in the real world. Methods The real world study included the patients with macular edema due to retinal vein occlusion of dampness syndrome who were treated in hospital from July 2020 to December 2021. They were divided into the observation group（differentiation and treatment from dampness combined with anti VEGF treatment）and the control group（anti VEGF treatment）. After 3 months of treatment，the retinal thick⁃ ness（CMT），intraretinal fluid（IRF）height and subretinal fluid（SRF）height of macular fovea were observed before and after treatment. Results CMT，IRF and SRF in the observation group were lower than those before treatment，while CMT，IRF and SRF in the control group were lower than those before treatment. After 3 months of follow⁃up，CMT and IRF in the observation group were lower than those in the control group，with a statistical difference（P < 0.05）. Conclusion The combination of anti VEGF therapy and differentiation and treatment from dampness can effectively improve the morphology of retinal vein macular edema of dampness syndrome，especially reduce the retinal fluid more significantly.

Key words:

retinaveinocclusion, macularedema, intraretinal fluid, subretinalfluid, dampness syndrome, real world study