实用医学杂志 ›› 2021, Vol. 37 ›› Issue (14): 1857-1860.doi: 10.3969/j.issn.1006⁃5725.2021.14.017

• 药物与临床 • 上一篇    下一篇

榄香烯联合奈达铂腔内注射对恶性胸水患者效果观察及生存质量的影响

吴慧杰1, 徐海英2, 张凌云2 ,邱慧兵2, 姚帆1   

  1. 湖北文理学院附属医院,襄阳市中心医院1 手术麻醉科,2 胸部肿瘤科(湖北襄阳 441021)
  • 出版日期:2021-07-25 发布日期:2021-07-25
  • 通讯作者: 徐海英 E⁃mail:583856284@qq.com

Effect of intracavitary infusion of elemene combined with nedaplatin on clinical efficacy and quality of life of patients with malignant ascites 

WU Huijie*,XU Haiying,ZHANG Lingyun,QIU Huibing,YAO Fan.    

  1. Department of Surgical Anesthesiology,Xiangyang Central Hospital,Affilicated Hospital of Hubei University of Arts and Sciemce,Xiangyang 441021,China

  • Online:2021-07-25 Published:2021-07-25
  • Contact: XU Haiying E⁃mail:583856284@qq.com

摘要:

目的 探讨分析榄香烯联合奈达铂腔内注射对恶性胸水患者治疗效果观察及生存质量的 影响。方法 选择 2014 2 月至 2017 1 月我院收治的老年肺癌患者出现恶性胸水 85 例,随机分为观察 44 例,对照组 41 例,对照组给予奈达铂、地塞米松腔内注射,观察组在对照组基础上联合使用榄香烯注 射液,比较两组胸水缓解情况、生活质量变化情况、不良反应及生存情况。结果 观察组患者胸水缓解总 有效率显著高于对照组(P < 0.05)。治疗后观察组患者总体健康、生理功能、躯体疼痛、生理职能、活力、 情感职能、生理功能以及精神健康各维度生活质量评分均显著高于对照组(P < 0.05)。两组患者治疗毒 副作用发生率差异无统计学意义(P > 0.05)。观察组患者生存情况显著优于对照组(P < 0.05)。结论 榄香烯联合奈达铂腔内注射治疗恶性胸水其临床疗效显著,患者耐受性较好,有助于患者生存质量的改 善,且可显著改善患者远期生存预后,值得临床推广运用。

关键词:

榄香烯, 奈达铂, 腔内灌注, 恶性胸水, 疗效, 生存质量

Abstract:

Objective To investigate and analyze the effect of intracavitary infusion of elemene combined with nedaplatin on clinical efficacy and quality of life of patients with malignant ascites. Methods Eighty ⁃five patients with malignant ascites from February 2014 to January 2017 were randomly divided into observation group (n = 44)and control group(n = 41). The control group was given intracavitary injection of nedaplatin and dexa⁃ methasone and the observation group was treated with elemene injection on the basis of the control group. The two groups were compared in terms of remission of pleural and ascites,changes in quality of life,adverse reactions and living conditions. Results The total effective rate of relieving pleural and ascites in the observation group was significantly higher than that in the control group(P < 0.05). After treatment,the scores of the six dimensions of general health,emotional and social functions,physiological functions,vitality,physiological functions and men⁃ tal health in relation with the quality of life in the observation group were all significantly higher than those in the control group(P < 0.05). The living conditions of patients in the observation group was significantly better than that in the control group(P < 0.05). Conclusion Elemene combined with nedaplatin intracavitary injection in the treatment of malignant ascites is more effective clinically,more tolerable for the patients and conducive to their improved quality of life. Moreover,it can significantly improve their long⁃term survival and prognosis. Therefore it is worthy of clinical application.

Key words:

elemene, nedaplatin, intracavitary perfusion, malignant ascites, efficacy, quality of life