2 ~ 5 cm 胃间质瘤内镜与外科治疗疗效对比

doi:10.3969/j.issn.1006⁃5725.2022.19.014

摘要/Abstract

摘要：

目的评价内镜与外科治疗直径 2 ~ 5 cm 胃间质瘤的疗效，探讨内镜下切除 2 ~ 5 cm 胃间质瘤的临床价值。方法收集2012年7月至2021年1月在郑州大学第一附属医院接受内镜或外科治疗直径 2 ~ 5 cm 且经术后病理证实为胃间质瘤的病例共 225 例。按照手术方式分为内镜组和外科组，其中内镜组共收集 104 例，外科组共收集 121 例。对比分析两组病例的一般资料，手术时间，术后住院时间，术后禁食时间，并发症及长期随访肿瘤复发情况。结果两组在年龄、性别、肿瘤发生部位、手术时间、完整切除率上差异无统计学意义（P > 0.05）。两组在肿瘤直径、肿瘤生长方式、临床表现、危险度分级、核分裂像数上差异具有统计学意义（P < 0.05）。内镜组术后住院时间、术后禁食时间小于外科组，差异具有统计学意义；内镜组并发症发生率（6.7%）低于外科组（20.7%），差异有统计学意义。中位随访 40 月，内镜组复发 1 例（复发率 1.0%）；外科组复发 2 例（复发率 1.7%），两组复发率相比差异无统计学意义（P > 0.05）。结论内镜下治疗直径 2 ~ 5 cm 无转移胃间质瘤是一种安全且有效的方法，患者预后同外科相当，可作为治疗胃间质瘤的主要方法之一。

关键词:

胃间质瘤, 内镜治疗, 外科手术, 疗效, 安全性

Abstract:

Objective To evaluate the efficacy of endoscopic and surgical treatment of gastric stromal tumors with a diameter of 2 ~ 5 cm，and to explore the clinical value of endoscopic resection of gastric stromal tumors of 2 ~ 5 cm in diameter. Methods A total of 225 cases of gastric stromal tumor with a diameter of 2 ~ 5 cm and confirmed by postoperative pathology in the First Affiliated Hospital of Zhengzhou University from July 2012 to January 2021 were collected. They were divided into endoscopic group（n = 104）and surgical group（n = 121）. The general data，operation time，postoperative hospital stay，postoperative fasting time，intraoperative and postop⁃ erative complications and long ⁃ term follow ⁃ up tumor recurrence were compared and analyzed between the two groups. Results There was no significant difference between the two groups in age，sex，tumor site，operation time，and complete resection rate（P > 0.05）. There were statistically significant differences in tumor diameter， tumor growth pattern，clinical manifestations，risk grading，and mitotic figures between the two groups（P < 0.05）. The postoperative hospital stay and postoperative fasting time in the endoscopic group were shorter than those in the surgical group，and the differences were statistically significant. The incidence of complications in the endoscopic group（6.7%）was lower than that in the surgical group（20.7%），showing statistical difference. With a median follow⁃up of 40 months，1 case of recurrence in the endoscopic group（the recurrence rate was 1.0%）and 2 in the surgical group（the recurrence rate was 1.7%）were found，and there was no significant difference in the recur⁃ rence rate between the two groups（P > 0.05）. Conclusion Endoscopic treatment of non⁃metastatic gastric stromal tumors with a diameter of 2⁃5cm is a safe and effective method. The prognosis of patients with endoscopic treatment is comparable to that with surgical treatment. It can be used as one of the main methods for the treatment of gastric stromal tumors.

Key words: gastric stromal tumor, , endoscopic treatment, , surgery, , curative effect, , safety

张婧文曹新广符洋焦文云刘靓郭长青 . 2 ~ 5 cm 胃间质瘤内镜与外科治疗疗效对比 [J]. 实用医学杂志, 2022, 38(19): 2451-2456.

ZHANG Jingwen, CAO Xinguang, FU Yang, JIAO Wenyun, LIU Liang, GUO Changqing..

Comparison of therapeutic effects between endoscopic and surgical treatment of 2 ~ 5 cm gastric stromal tumor [J]. The Journal of Practical Medicine, 2022, 38(19): 2451-2456.

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2 ~ 5 cm 胃间质瘤内镜与外科治疗疗效对比

Comparison of therapeutic effects between endoscopic and surgical treatment of 2 ~ 5 cm gastric stromal tumor

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