关键词: 发热伴血小板减少综合征, 新型布尼亚病毒, 临床特征, 预后影响因素

Abstract:

Objective To explore the epidemiological characteristics and prognostic factors of fever andthrombocytopenia syndrome（SFTS）caused by new bunya virus（SFTSV），and provide clinical basis for earlyidentification，diagnosis and treatment. Methods The case data of 80 SFTS patients admitted to the Departmentof Infectious Diseases，Anhui Medical University First Hospital from January 2019 to June 2020 were collected anddivided into survival group（n = 59）and death group（n = 21）. The two groups were compared in terms of generalinformation，symptoms and signs，laboratory indicators and viral load. The correlation between laboratory testresults and prognosis was analyzed by Spearman correlation analysis and prognostic related factors were analyzedwith multivariate binary logistic regression. Results The length of stay in the survival group was statistically signif⁃icantly longer than that of the death group（P < 0.05）. The levels of eGFR1，Ca，PLT，CD4，and CD8 in the survivalgroup were significantly higher than those in the death group（P < 0.05）. The levels of K，ALT，AST，ALP，GGT，LDH，CRE，CK，CKMB，fasting blood glucose，CRP，PCT，I1B，I6，I8，IL⁃10，IL⁃2R，TNA，APTT，TT，D⁃D，FDP and the viral load of Bunia virus in the survival group were all significantly lower than the deathgroup（P < 0.05）. Conclusion Nervous system manifestations（positive meningeal stimulation sign or disturbanceof consciousness at different degree），APTT level and the logarithm of viral load may be the factors influencing theprognosis of the disease.

Key words: fever with thrombocytopenia syndrome, new bunya virus, clinical features, prognostic
factors