肥大细胞在脓毒症中的作用研究进展

doi:10.3969/j.issn.1006-5725.2024.05.002

Abstract

Abstract:

Sepsis is a life-threatening organ dysfunction， which is caused by the body's uncontrolled immune response to infection. Tissue masts cells （MC）， derived from blood mast cell progenitors， are one of the classical effector cells in inflammatory response. MC plays an important role in sepsis via secreting a variety of inflammatory mediators and cytokines. Here， we summarized the potential roles of MC in sepsis， which is expected to provide novel ideas for the future research on the novel mechanisms of MC in sepsis.

Key words: sepsis, mast cell, potential roles

CLC Number:

R459.7

Junling WANG,Mengmeng ZHAN,Zhaolong ZHANG,Shaoheng HE,Bingyu. QIN. The research progress of the actions of mast cells in sepsis[J]. The Journal of Practical Medicine, 2024, 40(5): 596-600.

Figures/Tables 2

References 45

1	SINGER M， DEUTSCHMAN C S， SEYMOUR C W， et al. The Third International Consensus Definitions for Sepsis and Septic Shock （Sepsis-3）［J］. JAMA， 2016， 315（8）： 801-810.
2	蒋龙元. 免疫紊乱在脓毒症中的作用［J］. 实用医学杂志，2021，37（6）：701-704. doi:10.3969/j.issn.1006-5725.2021.06.001 doi: 10.3969/j.issn.1006-5725.2021.06.001
3	PRESCOTT H C， ANGUS D C. Enhancing Recovery From Sepsis： A Review［J］. JAMA， 2018， 319（1）： 62-75. doi:10.1001/jama.2017.17687 doi: 10.1001/jama.2017.17687
4	GALLI S J， GAUDENZIO N， TSAI M. Mast Cells in Inflammation and Disease： Recent Progress and Ongoing Concerns［J］. Annu Rev Immunol， 2020， 38： 49-77. doi:10.1146/annurev-immunol-071719-094903 doi: 10.1146/annurev-immunol-071719-094903
5	JIMENEZ M， CERVANTES-GARCIA D， CORDOVA-DAVALOS L E， et al. Responses of Mast Cells to Pathogens： Beneficial and Detrimental Roles［J］. Front Immunol， 2021， 12： 685865. doi:10.3389/fimmu.2021.685865 doi: 10.3389/fimmu.2021.685865
6	ELIEH ALI KOMI D， KUEBLER W M. Significance of Mast Cell Formed Extracellular Traps in Microbial Defense［J］. Clin Rev Allergy Immunol， 2022， 62（1）： 160-179. doi:10.1007/s12016-021-08861-6 doi: 10.1007/s12016-021-08861-6
7	WOZNIAK E， OWCZARCZYK-SACZONEK A， LANGE M， et al. The Role of Mast Cells in the Induction and Maintenance of Inflammation in Selected Skin Diseases［J］. Int J Mol Sci， 2023， 24（8）：7021. doi:10.3390/ijms24087021 doi: 10.3390/ijms24087021
8	RIBATTI D. Mast Cells and Resistance to Immunotherapy in Cancer［J］. Arch Immunol Ther Exp （Warsz）， 2023， 71（1）： 11. doi:10.1007/s00005-023-00676-x doi: 10.1007/s00005-023-00676-x
9	VAN DER ELST G， VAROL H， HERMANS M， et al. The mast cell： A Janus in kidney transplants［J］. Front Immunol， 2023， 14： 1122409. doi:10.3389/fimmu.2023.1183969 doi: 10.3389/fimmu.2023.1183969
10	STEVENS W W， KRAFT M， EISENBARTH S C. Recent insights into the mechanisms of anaphylaxis［J］. Curr Opin Immunol， 2023， 81： 102288. doi:10.1016/j.coi.2023.102288 doi: 10.1016/j.coi.2023.102288
11	ELIEH ALI KOMI D， WöHRL S， BIELORY L. Mast Cell Biology at Molecular Level： a Comprehensive Review［J］. Clin Rev Allergy Immunol： a Comprehensive Review， 2020， 58（3）： 342-365. doi:10.1007/s12016-019-08769-2 doi: 10.1007/s12016-019-08769-2
12	GALLI S J， KALESNIKOFF J， GRIMBALDESTON M A， et al. Mast cells as "tunable" effector and immunoregulatory cells： recent advances［J］. Annu Rev Immunol， 2005， 23： 749-786. doi:10.1146/annurev.immunol.21.120601.141025 doi: 10.1146/annurev.immunol.21.120601.141025
13	DAHLIN J S， MALINOVSCHI A， OHRVIK H， et al. Lin- CD34hi CD117int/hi FcepsilonRI+ cells in human blood constitute a rare population of mast cell progenitors［J］. Blood， 2016， 127（4）： 383-391. doi:10.1182/blood-2015-06-650648 doi: 10.1182/blood-2015-06-650648
14	WU C， BOEY D， BRIL O， et al. Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors［J］. Blood Advances， 2022， 6（15）： 4439-4449. doi:10.1182/bloodadvances.2022006969 doi: 10.1182/bloodadvances.2022006969
15	BONE-LARSON C L， HOGABOAM C M， STEINHAUSER M L， et al. Novel protective effects of stem cell factor in a murine model of acute septic peritonitis. Dependence on MCP-1［J］. Am J Pathol， 2000， 157（4）： 1177-1186. doi:10.1016/s0002-9440(10)64633-0 doi: 10.1016/s0002-9440(10)64633-0
16	TEEGALA L R， ELSHOWEIKH Y， GUDNEPPANAVAR R， et al. Protein Kinase C α and β compensate for each other to promote stem cell factor-mediated KIT phosphorylation， mast cell viability and proliferation［J］. FASEB J， 2022， 36（5）： e22273. doi:10.1096/fj.202101838rrr doi: 10.1096/fj.202101838rrr
17	DERAKHSHAN T， BOYCE J A， DWYER D F. Defining mast cell differentiation and heterogeneity through single-cell transcriptomics analysis［J］.J Allergy Clin Immunol， 2022， 150（4）： 739-747. doi:10.1016/j.jaci.2022.08.011 doi: 10.1016/j.jaci.2022.08.011
18	NULLENS S， DE MAN J， BRIDTS C， et al. Identifying Therapeutic Targets for Sepsis Research： A Characterization Study of the Inflammatory Players in the Cecal Ligation and Puncture Model［J］. Mediators Inflamm， 2018， 2018： 5130463. doi:10.1155/2018/5130463 doi: 10.1155/2018/5130463
19	ELIEH ALI KOMI D， KUEBLER W M. Significance of Mast Cell Formed Extracellular Traps in Microbial Defense［J］. Clin Rev Allergy Immunol， 2022， 62（1）： 160-179. doi:10.1007/s12016-021-08861-6 doi: 10.1007/s12016-021-08861-6
20	DI NARDO A， VITIELLO A， GALLO R L. Cutting edge： mast cell antimicrobial activity is mediated by expression of cathelicidin antimicrobial peptide［J］. J Immunol， 2003， 170（5）： 2274-2278. doi:10.4049/jimmunol.170.5.2274 doi: 10.4049/jimmunol.170.5.2274
21	STOVER C M， LUCKETT J C， ECHTENACHER B， et al. Properdin plays a protective role in polymicrobial septic peritonitis［J］. J Immunol， 2008， 180（5）： 3313-3318. doi:10.4049/jimmunol.180.5.3313 doi: 10.4049/jimmunol.180.5.3313
22	WEI O L， HILLIARD A， KALMAN D， et al. Mast cells limit systemic bacterial dissemination but not colitis in response to Citrobacter rodentium［J］. Infect Immun， 2005， 73（4）： 1978-1985. doi:10.1128/iai.73.4.1978-1985.2005 doi: 10.1128/iai.73.4.1978-1985.2005
23	SHELLEY O， MURPHY T， LEDERER J A， et al. Mast cells and resistance to peritoneal sepsis after burn injury［J］. Shock， 2003， 19（6）： 513-518. doi:10.1097/.01.shk0000055239.25446.2d doi: 10.1097/.01.shk0000055239.25446.2d
24	ABRAHAM S N， JOHN A L ST. Mast cell-orchestrated immunity to pathogens［J］. Nat Rev Immunol， 2010， 10（6）： 440-452. doi:10.1038/nri2782 doi: 10.1038/nri2782
25	ELIEH ALI KOMI D， WOHRL S， BIELORY L. Mast Cell Biology at Molecular Level： a Comprehensive Review［J］. Clin Rev Allergy Immunol， 2020， 58（3）： 342-365. doi:10.1007/s12016-019-08769-2 doi: 10.1007/s12016-019-08769-2
26	PILIPONSKY A M， CHEN C C， NISHIMURA T， et al. Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis［J］. Nat Med， 2008， 14（4）： 392-398. doi:10.1038/nm1738 doi: 10.1038/nm1738
27	MAURER M， WEDEMEYER J， METZ M， et al. Mast cells promote homeostasis by limiting endothelin-1-induced toxicity［J］. Nature， 2004， 432（7016）： 512-516. doi:10.1038/nature03085 doi: 10.1038/nature03085
28	PILIPONSKY A M， ACHARYA M， SHUBIN N J. Mast Cells in Viral， Bacterial， and Fungal Infection Immunity［J］. Int J Mol Sci， 2019， 20（12）：2851. doi:10.3390/ijms20122851 doi: 10.3390/ijms20122851
29	ORINSKA Z， MAURER M， MIRGHOMIZADEH F， et al. IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities［J］. Nat Med， 2007， 13（8）： 927-934. doi:10.1038/nm1615 doi: 10.1038/nm1615
30	HEUER J G， ZHANG T， ZHAO J， et al. Adoptive transfer of in vitro-stimulated CD4⁺CD25⁺ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis［J］. J Immunol， 2005， 174（11）： 7141-7146. doi:10.4049/jimmunol.174.11.7141 doi: 10.4049/jimmunol.174.11.7141
31	CARVALHO M， BENJAMIM C， SANTOS F， et al. Effect of mast cells depletion on the failure of neutrophil migration during sepsis［J］. Eur J Pharmacol， 2005， 525（1/3）： 161-169. doi:10.1016/j.ejphar.2005.09.049 doi: 10.1016/j.ejphar.2005.09.049
32	SALINAS E， QUINTANAR J L， RAMIREZ-CELIS N A， et al. Allergen-sensitization in vivo enhances mast cell-induced inflammatory responses and supports innate immunity［J］. Immunol Lett， 2009， 127（1）： 48-54. doi:10.1016/j.imlet.2009.08.012 doi: 10.1016/j.imlet.2009.08.012
33	NAUTIYAL K M， MCKELLAR H， SILVERMAN A J， et al. Mast cells are necessary for the hypothermic response to LPS-induced sepsis［J］. Am J Physiol Regul Integr Comp Physiol， 2009， 296（3）： R595-602. doi:10.1152/ajpregu.90888.2008 doi: 10.1152/ajpregu.90888.2008
34	DAHDAH A， GAUTIER G， ATTOUT T， et al. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis［J］. J Clin Invest， 2014， 124（10）： 4577-4589. doi:10.1172/jci75212 doi: 10.1172/jci75212
35	CAUGHEY G H. Mast cell proteases as protective and inflammatory mediators［J］. Adv Exp Med Biol， 2011， 716： 212-234. doi:10.1007/978-1-4419-9533-9_12 doi: 10.1007/978-1-4419-9533-9_12
36	MALLEN-ST CLAIR J， PHAM C T， VILLALTA S A， et al. Mast cell dipeptidyl peptidase I mediates survival from sepsis［J］. J Clin Invest， 2004， 113（4）： 628-634. doi:10.1172/jci19062 doi: 10.1172/jci19062
37	DAHDAH A， GAUTIER G， ATTOUT T， et al. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis［J］. J Clin Invest， 2014， 124（10）： 4577-4589. doi:10.1172/jci75212 doi: 10.1172/jci75212
38	SIEBECK M， HOFFMANN H， JOCHUM M， et al. Inhibition of proteinases with recombinant eglin C during experimental Escherichia coli septicemia in the pig［J］. Eur Surg Res， 1989， 21（1）： 11-17. doi:10.1159/000128998 doi: 10.1159/000128998
39	SEELEY E J， SUTHERLAND R E， KIM S S， et al. Systemic mast cell degranulation increases mortality during polymicrobial septic peritonitis in mice［J］. J Leukoc Biol， 2011， 90（3）： 591-597. doi:10.1189/jlb.0910531 doi: 10.1189/jlb.0910531
40	ZHANG Y J， LI M， MENG M， et al. The effect of ulinastatin on the small intestine injury and mast cell degranulation in a rat model of sepsis induced by CLP［J］. Exp Toxicol Pathol， 2009， 61（5）： 481-490. doi:10.1016/j.etp.2008.07.007 doi: 10.1016/j.etp.2008.07.007
41	YU H， LIU Y， WANG M， et al. Myeloperoxidase instigates proinflammatory responses in a cecal ligation and puncture rat model of sepsis［J］. Am J Physiol Heart Circ Physiol， 2020， 319（3）： H705-H721. doi:10.1152/ajpheart.00440.2020 doi: 10.1152/ajpheart.00440.2020
42	HOLLMANN T J， MUELLER-ORTIZ S L， BRAUN M C， et al. Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock： opposing roles of C3a and C5a［J］. Mol Immunol， 2008， 45（7）： 1907-1915. doi:10.1016/j.molimm.2007.10.037 doi: 10.1016/j.molimm.2007.10.037
43	YUE J， TAN Y， HUAN R， et al. Mast cell activation mediates blood-brain barrier impairment and cognitive dysfunction in septic mice in a histamine-dependent pathway［J］. Front Immunol， 2023， 14： 1090288. doi:10.3389/fimmu.2023.1090288 doi: 10.3389/fimmu.2023.1090288
44	DUBAYLE D， HERON A. Decrease of cerebral mast cell degranulation after systemic administration of lipopolysaccharide［J］. Inflamm Res， 2012， 61（12）： 1295-1297. doi:10.1007/s00011-012-0565-0 doi: 10.1007/s00011-012-0565-0
45	RONNBERG E， JOHNZON C F， CALOUNOVA G， et al. Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo［J］. Immunology， 2014， 143（2）： 155-163. doi:10.1111/imm.12297 doi: 10.1111/imm.12297

[1]	Xianqi WANG,Bin ZHANG,Qi ZHANG,Zheng DAI,Jinxin ZHANG,Xiaoli LIANG,Lin LI,Lin WU,Shanshou LIU. Analysis of the changes in the count and function of platelet at the early sepsis based on single cell sequencing [J]. The Journal of Practical Medicine, 2024, 40(9): 1218-1224.
[2]	Jiadong WANG,Fangzhou HUANG,Yan HUANG,Guanxiong CHEN,Jun LIU,Peiqi. HUANG. Role of eupatilin in protection of mitochondrial function through Sesn2⁃Nrf2 in septic brain injury [J]. The Journal of Practical Medicine, 2024, 40(5): 601-607.
[3]	Ying ZHOU,Dajun JIANG,Yong TIAN,Yongxiang GU,Guohui. YANG. Inhibition of TRAF6 ameliorates myocardial inflammatory injury and cardiac dysfunction via regulating cardiomyocyte inflammation in sepsis mice [J]. The Journal of Practical Medicine, 2024, 40(5): 608-614.
[4]	Bo YANG,Zhaoquan. JIN. The clinical efficacy of sivelestat sodium combined with ulinastatin for sepsis⁃induced acute respiratory distress syndrome [J]. The Journal of Practical Medicine, 2024, 40(5): 621-626.
[5]	Guangping WU,Xin YIN,Jianzhuo HE,Liheng. GUO. The effect of Xinmailong injection on microcirculation in patients with septic shock [J]. The Journal of Practical Medicine, 2024, 40(5): 627-631.
[6]	Chengcai DAI,Zhenxing CHENG,Qianqian TU. The prognostic value of serum cystatin C combined with bedside renal ultrasound in patients with sepsis⁃induced acute kidney injury [J]. The Journal of Practical Medicine, 2024, 40(22): 3226-3231.
[7]	Zhouyou WU,Ting LI,Tengwei ZHANG,Qiaoyan FANG,Liu YANG,Qiao LI. Hydroxynonenal alleviates neonatal sepsis⁃induced acute lung injury by inhibiting endothelial cell pyrosis [J]. The Journal of Practical Medicine, 2024, 40(2): 195-201.
[8]	Fangmin GENG,Yuandan HE,Wenjuan LI,Qianqian LIU,Hongwei ZHANG,Zhangping LU,Lianhua WEI. Values of different DIC scoring systems in early diagnosis and prognosis prediction of coagulation dysfunction in sepsis patients [J]. The Journal of Practical Medicine, 2024, 40(2): 248-252.
[9]	Xing CAI,Xinglong MA,Changjian ZHOU,Peng XIE,Songxuan SHEN,Yanmei MIAO,Jiamei SONG,Leiyu. XIE. The research progress of macrophage glycolysis in sepsis [J]. The Journal of Practical Medicine, 2024, 40(19): 2783-2788.
[10]	Min LIU,Xiyun CHEN,Jianlei LÜ,Jie. FENG. ALKBH5 reduce septic-induced myocardial dysfunction by regulating the TRAF1/NF-κB pathway [J]. The Journal of Practical Medicine, 2024, 40(17): 2381-2389.
[11]	Feng ZHOU,Qixiang YIN,Faxing WEI,Haimin LIN,Huazhong CAI,Yikun. CHEN. The value of serum AQP1 level combined with EVLWI in assessing the severity and prognosis of ARDS due to sepsis [J]. The Journal of Practical Medicine, 2024, 40(17): 2483-2488.
[12]	Wei JIANG,Hui WANG,Zhongwei HUANG,Xinzhong. HUANG. The predictive value of soluble ST2 in sepsis⁃associated acute kidney injury [J]. The Journal of Practical Medicine, 2024, 40(16): 2291-2297.
[13]	Jiao XU,Min ZHANG,Guogang. XIE. Research progress of mast cell⁃derived exosomes in bronchial asthma [J]. The Journal of Practical Medicine, 2024, 40(15): 2194-2198.
[14]	Chun LONG,Hongying BI,Changzhen YANG,Jiakai WANG,Yan TANG,Xu. LIU. Emodin upregulates the Sirt2 to attenuate LPS-induced oxidative stress response in RAW264.7 cells [J]. The Journal of Practical Medicine, 2024, 40(13): 1785-1790.
[15]	Guomin ZHAO,Hui ZHANG,Pucong YE,Wei. CHEN. Effect of lactate dehydrogenase to albumin ratio on the short⁃term prognosis in patients with sepsis⁃associated acute kidney injury [J]. The Journal of Practical Medicine, 2024, 40(13): 1803-1807.

The research progress of the actions of mast cells in sepsis

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 2

References 45

Related Articles 15

Recommended Articles

Metrics

Comments