Abstract:

Objective To investigate the role and significance of Bone Mineral Density（BMD）and serum 25⁃hydroxy vitamin D（25（OH）D）and Irisin levels expression in muscle mass and bone loss in the elderly male population with different degrees of sarcopenia（SP）. Methods 225 male elderly patients with sarcopenia were selected from the outpatient and inpatient departments of endocrinology in the Affiliated Hospital of Zunyi Medical University，and then divided into three groups according to the different degrees of sarcopenia：the pre⁃ sarcopenia group（75 cases in group A），the sarcopenia group（75 cases in group B），and the severe sarcopenia group（75 cases in group C）. Healthy check⁃ups from medical examination centers were also selected and matched for age and included in the normal control group（75 cases in the NC group），and serum Irisin levels were measured by Enzyme⁃Linked Immunosorbent Assay（Elisa）in all subjects. Results BMD was significantly lower in group C than in groups A，B，and NC（all P < 0.05）；the difference between BMD was significantly lower in group A than in group NC was statistically significant，and there was no statistical difference between group A and group B. The differences between serum Irisin and 25（OH）D levels in patients with different SP severity grades were statistically significant（all P < 0.05）. Pearson results showed that serum Irisin was positively correlated with BMD （L1⁃4，Neck），SMI，grip strength，gait speed，25（OH）D，HDL⁃C，and negatively correlated with BMI and LDL⁃C； serum 25（OH）D level was positively correlated with BMD（L1⁃4，Neck），SMI，grip strength，gait speed，HDL⁃C， Irisin，and negatively correlated with BMI and TG. Conclusion Muscle mass and bone loss are associated withlow levels of 25（OH）D and Irisin expression in the elderly male population，and their combined testing can help in the diagnosis and treatment of sarcopenia.

Key words:

older men, sarcopenia, bone mineral density, 25?hydroxy vitamin D, Irisin