Abstract:

Objective To investigate the diagnostic value of serum miR ⁃ 134 and miR ⁃301 level in liver fibrosis in patients with chronic hepatitis C（CHC）. Methods One hundred and fifty patients with CHC admitted to our hospital were selected as CHC group，and 150 healthy people as control group during the same period. The level of ALT，AST，TBIL，miR⁃134 and miR⁃301 was compared between the two groups. The CHC group was divided into different subgroups according to the liver fibrosis stage（S0 ⁃ S4 grade），and the level of various indexes among subgroups were compared. The ROC curve was used to analyze the clinical value of ALT，AST，TBIL，miR⁃134 and miR⁃301 level in the diagnosis of significant liver fibrosis（S2⁃S4 stage）. Results Compared with that in the control group，the level of ALT，AST，TBIL，miR⁃134 and miR⁃301 in the CHC group increased significantly（P < 0.05）. As the stage of liver fibrosis increased，the level of ALT，AST，TBIL，miR⁃134 and miR⁃301 increased（P < 0.05）. ROC curve results showed that the AUC of ALT，AST，and TBIL in the diagnosis of significant liver fibrosis was < 0.7，while the AUC of miR ⁃ 134 and miR ⁃ 301 level in the diagnosis of significant hepatic fibrosis > 0.70. Conclusion The serum level of miR⁃134 and miR⁃301 in patients with CHC increases significantly，and is closely related to the degree of liver fibrosis in patients. The detection of miR⁃134 and miR⁃301 has certain clinical value in the diagnosis of significant liver fibrosis.

Key words: chronic hepatitis C,  , liver fibrosis,  , miR?134,  , miR?301