Abstract:

Objective To explore the effect of Huoyuan Recipe combined with quadruple therapy on serum pepsinogen（PG），tumor⁃specific growth factor（TSGF）and gastric cancer monoclonal antibody（MG7⁃Ag） levels in patients with Hp⁃positive chronic atrophic gastritis with spleen⁃stomach qi deficiency type. Methods A total of 96 patients with Hp⁃positive chronic atrophic gastritis of spleen⁃stomach⁃qi deficiency type who were admitted to Wuhan hospital of traditional Chinese medicine from October 2020 to September 2021 were selected and divided into the control group and the observation group by random number table method，48 cases in each group. Blind experiments were performed on condition the patients knew nothing about their respective therapy. The control group was treated with quadruple therapy + placebo，and the observation group was treated with quadruple therapy + Huoyuan Recipe. The TCM symptom scores of the two groups were evaluated，and the gastrointestinal function detector was used to detect pepsinogen Ⅰ（PGⅠ），pepsinogen Ⅱ（PGⅡ），and gastrin⁃17（G⁃17）level. Enzyme⁃ linked immunosorbent assay was used to detect tumor necrosis factor⁃α（TNF⁃α），interleukin⁃6（IL⁃6），C⁃reactive protein（CRP），TSGF，MG7⁃Ag levels. The clinicopathological conditions of the patients were assessed by patho⁃ logical scoring. The Hp conversion was recorded，and the therapeutic effects of the two groups were compared. Results After treatment，the scores of stomach pain，bloating，fatigue，TSGF，MG7⁃Ag，TNF⁃α，IL⁃6，CRP levels，chronic inflammation，inflammatory activity，gland atrophy，and intestinal metaplasia scores in the observation group were significantly lower than those in the control group（P < 0.05）. After treatment，the levels of PGⅠ，PGⅡ and G⁃17 in the observation group were significantly higher than those in the control group（P < 0.05）. The negative rate and effective rate of Hp in the observation group were significantly higher than those in the control group （P < 0.05），and the incidence of adverse reactions in the observation group was lower than that in the control group （P > 0.05）. Conclusion Huoyuan Recipe combined with quadruple therapy can effectively treat Hp ⁃ positive chronic atrophic gastritis of spleen⁃stomach⁃qi deficiency type by decreasing the TCM syndrome score，improving the levels of PGⅠ，PGⅡ，TSGF，MG7⁃Ag and G⁃17，alleviating the inflammatory response，and improving the patient′s pathology score，and increasing the Hp eradication rate.

Key words: Huoyuan Recipe,  , quadruple therapy,  , chronic atrophic gastritis,  , spleen ? stomach qi deficiency type,  , Helicobacter pylori,  , inflammatory response