The Journal of Practical Medicine ›› 2022, Vol. 38 ›› Issue (16): 1993-1997.doi: 10.3969/j.issn.1006⁃5725.2022.16.002

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Drug loaded nanodelivery system in glioma treatment

SHU Bo*,GAN Hongchuan,CHU Liangzhao,ZHOU Shunjun.   

  1. Department of Neurosurgery,the Second People′s Hospital of Guiyang,Guiyang 550081,China 

  • Online:2022-08-25 Published:2022-08-25
  • Contact: CHU Liangzhao E⁃mail:365446506@qq.com

Abstract:

Glioma is the most common and destructive primary brain tumor. The clinical treatments of glioma include surgery,radiotherapy and chemotherapy,but none of them can prolong the life span of patients effectively. The inherent heterogeneity,invasion of glioma,intact blood⁃brain barrier and chemotherapy resistance lead to the poor prognosis of glioma patients. Glioma microenvironment is characterized by hypoxia,low pH and high concentration of glutathione,which are different from normal tissues. In this paper,the drug⁃carrying nanode⁃ livery systems in the treatment of glioma has been summarized,including single⁃drug nanodelivery system,multi⁃ drug nanodelivery system and multi⁃mode nanodelivery system,with a conclusion that the intelligent nanodelivery systems can be realized by responding to the signals of glioma site and the reduced⁃toxicity to normal tissue and the therapeutic effect on glioma can be improved. The advantages and disadvantages of the three nanodelivery systemsin the treatment of glioma have been further discussed and compared. The challenges of these nanodelivery systems in the treatment of glioma in the have been summarized as well.

Key words:

glioma, chemotherapy resistance, nanodelivery system