Abstract:

Glioma is the most common primary malignant brain tumor. Standard of care including surgery， radiotherapy and chemotherapy has not resulted in a significant improvement in the survival outcome of patients. The invasive tumor growth，blood⁃brain barrier，and their intrinsic resistance to the induction of radio⁃chemothera⁃ py hinder the anti⁃cancer role of standard treatment. Currently，with increase in understanding of the genetic altera⁃ tion and immune microenvironment of glioma，many molecular markers have been identified and used in clinical practice for precise diagnosis，survival prediction and designing personalized therapy forpatients with glioma. The efficacies of novel targeted therapies are promising in several clinical trials. Immunotherapy and advanced physio⁃ therapies including tumor treating fields also achieved development. All these advances bring hope to improve the survival and quality of life for patients with glioma. In this review，we summarize the current status of treatment for gliomas and discuss the important advances in glioma oncology.

Key words:

glioma, molecular pathology, targeted therapy, immunotherapy, tumor?treating field