Abstract:

Glioma is the most prevalent and malignant primary intracranial tumor. At present，the main treatment method for glioma are surgery combined with radiotherapy and chemotherapy. However，similar to any other cancer，chemoresistance contributes majorly to cancer recurrence；TMZ resistance makes the therapeutic actuality worse for glioma patients. CircRNA，as a special kind of noncoding RNA，has a wide range of biological functions. It can affect the occurrence，development，invasion and metastasis of gliomas by interacting with some biomolecules such as oncogenes，miRNA or functional proteins or by coding proteins. The role of circRNA as molecular markers or potential targets will provide promising application perspectives，such as early tumor diagnosis， therapeutic evaluation，prognosis prediction，and even gene therapy for tumors.

Key words:

glioma, circRNA, miRNA, protein, biomarkers