Abstract:

Objective To study the predictive value of prechemotherapy platelet parameters on chemosen⁃ sitivity and prognosis of patients with Ⅳ stage colorectal cancer. Methods A retrospective analysis was conducted in 138 patients with stage Ⅳ colorectal cancer receiving chemotherapy in the Second Affiliated Hospital of Guangzhou Medical University from January 2010 to January 2021. ROC curve was used to analyze the relationship between platelet count（PLT），mean platelet volume（MPV），platelet distribution width（PDW）and plateletcrit（PCT）and chemosensitivity on colorectal cancer，and the best cut ⁃off value for predicting the chemosensitivity for colorectal cancer. A logistic regression model was established to analyze the independent related factors that affected the efficacy of chemotherapy for colorectal cancer. Univariate and Cox regression models were used to analyze the rela⁃ tionship between platelet parameters and other clinicopathological factors and patient survival and progression⁃free survival. Results Prechemotherapy PLT was significantly related to the chemosensitivity of patients with stage Ⅳ colorectal cancer. The best cut⁃off value for predicting chemosensitivity of prechemotherapy PLT was 317 × 109 /L； prechemotherapy PLT > 317 × 109 /L was more sensitive to chemotherapy（P < 0.000 1），and there is no statistical correlation between MPV，PDW and PCT before chemotherapy and chemotherapy sensitivity of stage Ⅳ colorectal cancer. However，compared with prechemotherapy PLT ≤ 317 × 109 /L，prechemotherapy PLT > 317 × 109 /L showed no significant differences of OS（P = 0.143），PFS（P = 0.941）by Kaplan⁃Meier survival analysis. Cox multivariateanalysis showed prechemotherapy PLT > 317 × 109 /L was not the independent risk factor affecting OS and PFS of stage Ⅳ colorectal cancer. Conclusions The prechemotherapy PLT in colorectal cancer is correlated with the che⁃ mosensitivity in stage Ⅳ colorectal cancer，but it has no obvious clinical value in prognosis evaluation.

Key words:

colorectal cancer, platelet, chemotherapy, prognosis