Abstract:

Objective To explore the efficacy of radical and conservative therapies for unicysticameloblas⁃ toma systematically. Methods The relevant studies on therapies for unicysticameloblastoma，which had published from the establishment of the databases to August 2021，were searched in PubMed，EMbase，CENTRAL and CBM. After screening the literatures and extracting the data，we performed a meta ⁃analysis by using RevMan5.4 software. Results According to the search strategies for searching articles in Chinese or English，72 articles were determined，11 of which met the inclusion criteria. A total of 485 patients with unicysticameloblastomas received either radical or conservative treatment，126 of whom underwent radical surgery and the rest 359 received conserva⁃ tive treatment. The recurrence rate was 3.17% for radical surgery and 19.22% for conservative treatment. The meta⁃ analysis showed a lower risk of recurrence of unicysticameloblastomas in radical treatment than in conservative treat⁃ ment（OR = 0.24，95%CI：0.11 ~ 0.52，P = 0.000 3），but perioperative blood loss was greater（MD = 167.12， 95%CI：140.80 ~ 193.44，P < 0.001）and surgical duration was longer（MD = 158.77，95%CI：96.48 ~ 221.06， P < 0.001）in radical treatment. Conclusions This study shows that although unicysticameloblastoma is a benign tumor，it′ s still very likely to recur. Different treatment strategies have significant statistical differences in recur⁃ rence rates. Conservative treatment is more prone to recurrence than radical treatment，whereas it is safer.

Key words:

ameloblastoma, unicysticameloblastoma, recurrence, perioperative blood loss, surgi? cal duration, meta analysis