Abstract:

Objective To investigate the effect of serum lactate dehydrogenase（LDH）combined withinterleukin⁃18（IL⁃18）in early predicting refractory mycoplasma pneumoniae pneumonia（RMPP）in children.Methods A total of 144 cases diagnosed with mycoplasma pneumoniae pneumonia in the hospital during December2018 to November 2019 were involved in the study，including 48 cases of RMPP and 96 cases of general Mycoplasmapneumoniae（GMPP）. Another group of 40 healthy children who came for health examination in our hospitalduring the same period were assigned as the control group. The levels of LDH and IL⁃18 in the three groups werecompared. ROC curve was used to predict the incidence of RMPP，and the critical value of specific index wasdetermined. Results There were significant differences in the LDH level among the three groups（P < 0.001）andthe level of IL⁃18 in the RMPP group was significantly different as compared to the levels of RMPP and controlgroups，but there was no significant difference between the GMPP and control groups. When LDH was 306.05 U/L，AUC（area under the curve）was 0.95，with the RMPP sensitivity and specificity of 95.8% and 85.4%，respectively；When the level of IL⁃18 was 416.95pg/ml，AUC was 0.99，with the RMPP sensitivity and specificity of 97.9% and99.0%，respectively. Conclusion Early and timely detection of LDH and IL⁃18 levels is of great clinical signifi⁃cance in the early prediction of severe RMPP，early intervention and evaluation of prognosis.

Key words: mycoplasma pneumoniae pneumonia, refractory, LDH, IL?18, prediction