Abstract:

Objective The study aimed to compare the difference and clinical significance of Xanthine oxidase and uric acid in heart failure（HF）patients with different ejection fraction. Methods A total of 120 HF patients were enrolled and divided into HFrEF group，HFmrEF group and HFpEF group，with 40 patients in each group respectively. Another 40 patients without heart failure but other types of cardiovascular diseases were selected as the control group. The clinical data were collected. The levels of uric acid（UA）and xanthine oxidase（XO） were determined by Enzyme Linked Immunosorbent Assay（ELISA）. Results Compared with the control group， XO and UA levels in the three groups were all statistically increased（F = 60.257，F = 19.024，both P < 0.01）. Spearman correlation analysis showed that serum XO and UA levels in patients with heart failure were positively correlated with NT⁃proBNP（r = 0.571，r = 0.404）and negatively correlated with LVEF（r = -0.185，r = -0.270）， with statistically significant differences（all P < 0.05）. Multivariate regression analysis showed that the risk factors for heart failure with different ejection fraction included XO and UA. In addition，history of coronary heart disease was a risk factor for heart failure with reduced ejection fraction，and history of atrial fibrillation was a risk factor for heart failure with retained ejection fraction. Conclusion XO and UA are risk factors for patients with heart failure. They have certain reference value for clinical diagnosis of patients with heart failure and may even be an important index to evaluate the degree of impairment of heart function in patients with heart failure.

Key words:

Xanthine oxidase, uric acid, heart failure, risk factors