Abstract:

Objective To explore the influence of obesity and bad living habits on the progression of liver fibrosis in metabolic associated fatty liver disease. Methods Patients undergoing FibroTouch in the Affiliated Hospital of Yunnan University from July 2017 to July 2018 were selected for cross⁃sectional analysis. According to the controlled attenuation parameters detected by FibroTouch，the patients were divided into healthy control group （n = 1731）and MAFLD group（n = 410），then according to the liver hardness value detected by FibroTouch， MAFLD group was divided into no or mild liver fibrosis group（n = 262）and progressive liver fibrosis group （n = 148）. Chi ⁃square test，Spearman correlation analysis and binary Logistic regression were used to analyze the influence of bad living habits on the progression of liver fibrosis. Results Statistically significant differences in gender，LSM and BMI were found between healthy control group and MAFLD group（P < 0.05）. There were significant correlations among age，LSM，BMI and CAP in MAFLD group（P < 0.001）. There were statistically significant differences in age，LSM，BMI，CAP and bad living habits between the group without or mild liver fibrosis and the group with advanced liver fibrosis （P < 0.05）. Binary Logistic regression analysis showed BMI and bad living habits were independent risk factors for progression of liver fibrosis in MAFLD（P < 0.05）. Conclusion Risk factors such as obesity and bad living habits increased the risk of liver fibrosis progression in patients with MAFLD.

Key words:

metabolic associated fatty liver disease, liver fibrosis, liver stiffness, bad living habits, risk factors