Abstract:

Objective To compare the effects of different immunotherapy on mmunologic function and prognosis in elderly immunosuppressive patients with sepsis. Methods Ninety⁃one elderly patients with immuno⁃ suppressive of sepsis were randomly divided into control group（A group，n = 30）and thymalfasin treatment group （B group，n = 30）and thymalfasin combined with Xuebijing treatment group（C group，n = 31）. The changed of the mmunologic function such as CD3+ T cell count and CD4+ T cell count and the ratio of CD4+ /CD8+ T cell count and human leukocyte antigen DR expression rate，ICU length of hospital stay，total length of stay in hospital and 90⁃ day mortality were compared and analyzed. Results The CD3 + T cell count，CD4 + T cell count，the ratio of CD4+ /CD8+ T cell count and the expression rates of HLA⁃DR increased significantly after treatment and total length of stay in hospital and 90⁃day mortality rate were decreased significantly in group B and group C when compared with those in group A（P < 0.05）. The CD3+ T cell count，CD4+ T cell count，and the expression rates of HLA⁃DR increased significantly and the length of stay in ICU and total length of stay in hospital decreased significantly in group C when compared with those in group B after treatment（P < 0.05）. Conclusion In elderly immunosuppressive patients with sepsis，the use of thymalfasin or combined with Xuebijing injection can improve the mmunologic func⁃ tion and prognosis. Combination therapy has synergistic effect and is superior to single thymalfasin treatment.

Key words:

sepsis, immunosuppression, immunotherapy, thymalfasin, Xuebijing injection