Abstract:

Objective To explore the role and mechanism of pharmacokinetics/pharmacokinetics（PK/ PD）in ICU elderly patients with sepsis. Methods Sixty elderly patients with sepsis in ICU from January 2019 to March 2020 were randomly divided into the Therapeutic Drug Monitoring（TDM）group and control group According to different methods of administration. The dose of meropenem was adjusted in TDM group. The control group was not adjusted. The treatment effect，microbial cure rate and case fatality rate were compared between the two groups. Results The clinical indexes of TDM group were significantly lower than those of control group（P < 0.05）. The clinical cure rate（90.00%）and microbial cure rate（93.33%）in TDM group were significantly higher than those in control group（70.00%），and the difference was statistically significant（P < 0.05）. The incidence of adverse side effects（10.00%）and case fatality（3.33%）in TDM group were significantly lower than those in control group （23.33%，10.00%），and the difference was statistically significant（P < 0.05）. The patients who achieved PK/PD goal in TDM group（93.33%）were significantly higher than those in control group（53.33%），and the difference was statistically significant（P < 0.05）. Conclusion PK/PD theory can optimize the treatment of meropenem in ICU elderly with sepsis，improve the effective rate of treatment and microbial cure rate，reduce the incidence of adverse reactions and mortality.

Key words:

sepsis, elderly patients, respiratory intensive care unit, meropenem, pharmacokinetics, pharmacodynamics