基质金属蛋白酶-28在肺部疾病中的研究进展

doi:10.3969/j.issn.1006-5725.2024.20.021

Abstract

Abstract:

Matrix metalloproteinase-28 （MMP-28） is widely expressed in vertebrates and plays diverse biological roles， participating in the regulation of various pathophysiological processes in the body. Increased expression of MMP-28 has been observed in chronic obstructive pulmonary disease， pulmonary fibrosis， and other lung diseases. Studies have demonstrated that MMP-28 promotes chronic inflammation and tissue remodeling by regulating macrophage recruitment and M2 polarization， and is involved in the pathogenesis of lung diseases by promoting cell proliferation and epithelial-mesenchymal transition. This article provides a review of the relationship between the basic characteristics of MMP-28 and pulmonary diseases.

Key words: matrix metalloproteinase-28, pulmonary disease, regulatory mechanism

CLC Number:

R563

Ling TAN,Xue MA,Jingjing WANG,Fengfeng LEI. Research progress of matrix metalloproteinase⁃28 in pulmonary disease[J]. The Journal of Practical Medicine, 2024, 40(20): 2949-2953.

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Research progress of matrix metalloproteinase⁃28 in pulmonary disease

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