Abstract:

Objective The of this study was to explore the risk factors of pulmonary hypertension（PH） in acute exacerbation of chronic obstructive pulmonary disease （AECOPD） and to find potential predictors. Methods A retrospective analysis was made of 120 AECOPD patients who admitted to The Second Affiliated Hospital of Zhengzhou University from March 2019 to March 2022. According to the status of PH，patients were divided into AECOPD group（n = 59）and AECOPD complicated with pH group（n = 61）. Multivariate logistic regression analysis was applied to explore the influencing factors of AECOPD complicated with PH. The receiver characteristic operating curve（ROC curve）was used to analyze the diagnostic value of each index for AECOPD complicated with PH. Results C⁃reactive protein to albumin ratio（CAR），neutrophil⁃to⁃lymphocyte ratio（NLR）， platelet⁃to⁃lymphocyte ratio（PLR），C⁃reactive protein（CRP），interleukin⁃6（IL⁃6），albumin，lymphocyte count， neutrophil count，prothrombin time，D ⁃ dimer and N ⁃terminal pro ⁃ brain natriuretic peptide（NT ⁃ proBNP）were higher than those in AECOPD group（P < 0.05）. Regression analysis showed that CAR，NT⁃proBNP and D⁃dimer were independent risk factors for AECOPD complicated with PH（P < 0.05）. The results of ROC curve analysis showed that the AUCs of CAR，NT⁃proBNP and D⁃dimer were 0.854，0.885 and 0.729. Conclusions AECOPD patients with higher CAR，NT ⁃proBNP and D ⁃dimer were more likely to develop PH. CAR and NT ⁃proBNP are better than D⁃dimer in the diagnosis of AECOPD complicated with PH. 

Key words:

chronic obstructive pulmonary disease, pulmonary hypertension, C ? reactive protein to albumin ratio, neutrophil to lymphocyte ratio, risk factors