Abstract:

Objective To analyze the value of endothelial ⁃specific molecule ⁃ 1（Endocan）and fibrinogen （Fib）levels in the diagnosis and severity assessment of acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods A total of 79 patients with acute exacerbation of chronic obstructive pulmonary disease （COPD）treated in the department of respiratory and critical care medicine from April 2021 to April 2022 were collected as a AECOPD group. Thegroup was then divided into three subgroups based on disease severity. 30 patients with stable chronic obstructive pulmonary disease（SCOPD）who revisited our clinics during the same period were selected as a SCOPD group，and 30 individuals who underwent physical examination in our hospital were selected as acontrol group. Serum levels ofEndocan and Fib were comparedamong the groups，and the predictive value of the above factors in the diagnosis of AECOPD was analyzed. Results Levels of Endocan and Fib in the AECOPD and SCOPD groups were significantly higher than those in the control group（P < 0.05 for all comparisons），demonstra⁃ tingthe highest levelsin the AECOPD group. Levels of Endocan and Fib were significantly different among the AECO⁃ PD subgroups（P < 0.05），and increased with the severitylevel of AECOPD. The receiver operating characteristic curve analysis results showed that the area under the curve（AUC）of Endocan and Fib were 0.832 and 0.729，respec⁃ tively；and the AUC of the combined detection was higher，which was 0.855. Conclusions The expression levels of serum Endocan and Fib are related to the severity of AECOPD，which can be used as an important indicator for the diagnosis and assessment of disease course. The diagnostic efficiency of Endocan is better thanthat of Fib.

Key words:

acute exacerbation of chronic obstructive pulmonary disease, endocan, fibrinogen, COVID?19