The Journal of Practical Medicine ›› 2024, Vol. 40 ›› Issue (20): 2941-2948.doi: 10.3969/j.issn.1006-5725.2024.20.020

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The mechanism and treatment progress of endometrial receptivity change in adenomyosis

Jia ZHEN1,Ziyuan ZHAO2,Wei SHI3,Zilu WANG1,Zhiyong LIU4,Li XU5()   

  1. *.The First Clinical Medical College of Shandong University of Traditional Chinese Medicine,Ji′nan 250000,Shandong,China
  • Received:2024-04-17 Online:2024-10-25 Published:2024-11-05
  • Contact: Li XU E-mail:xulisw@126.com

Abstract:

Adenomyosis (AM) is characterized by the benign invasion of endometrial tissue and stroma into the myometrium, resulting in diffuse or localized pathological changes. Typical symptoms include increased menstrual volume, prolonged menstrual periods, and progressive dysmenorrhea. In severe cases, AM can lead to infertility. Endometrial receptivity (ER) plays a crucial role in facilitating adhesion, penetration, and implantation required for successful embryo implantation and pregnancy outcome. The impairment of ER due to AM-related factors involves complex mechanisms. This article aims to provide a comprehensive review of recent research findings on the mechanisms underlying ER injury caused by AM over the past three years while highlighting the latest advancements in treatment strategies.

Key words: adenomyosis, endometrial receptivity, pregnancy, HIFU, GnRH-a

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