2型糖尿病合并慢性牙周炎患者血清LRG1、LDH与牙周指标和牙周病变程度的关系

doi:10.3969/j.issn.1006-5725.2024.16.009

Abstract

Abstract:

Objective To explore the relationship between serum leucine 2-rich glycoprotein 1 （LRG1）， lactate dehydrogenase （LDH） with periodontal indicators and periodontal lesions degree in patients with type 2 diabetes mellitus （T2DM） and chronic periodontitis （CP）. Methods 112 patients with T2DM combined with CP admitted to our hospital from July 2022 to July 2023 （T2DM combined with CP group） were selected and categorized into mild， moderate， and severe groups according to the degree of periodontal pathology； 112 patients with CP alone （CP group） were selected from our hospital during the same period， and then 112 patients with T2DM alone （T2DM group） were selected； and LRG1， LDH， and periodontal indexes were measured； Pearson method was applied to analyze the correlation between serum LRG1， LDH， and periodontal indicators. The influencing factors of severe T2DM combined with CP were analyzed using multivariate logistic regression. ROC curve was plotted to analyze the diagnostic value of serum LRG1 and LDH for severe T2DM combined with CP. Results The levels of LRG1 and LDH in the CP group， T2DM group， and T2DM combined with CP group increased sequentially （P < 0.05）. The levels of serum LRG1， LDH， AL， PD， and BI increased sequentially in the mild， moderate， and severe groups （P < 0.05）. According to Pearson correlation analysis， serum LRG1 was positively correlated with LDH （P < 0.05）. Serum LRG1 and LDH were positively correlated with AL， PD， and BI （P < 0.05）. According to logistic regression analysis， LRG1， LDH， AL， PD， and BI were all factors for severe T2DM combined with CP （P < 0.05）. According to the ROC curve， the AUC for the combined diagnosis of serum LRG1 and LDH in severe T2DM with CP was 0.910， and the combination of the two was better than their individual diagnosis （Z_{combination vs LRG1}= 2.659， Z_{combination vs LDH}=2.627， P < 0.05）. Conclusion LRG1 and LDH are greatly elevated in the serum of patients with T2DM combined with CP， and they are related to periodontal indicators and the periodontal lesions degree.

Key words: type 2 diabetes mellitus, chronic periodontitis, leucine rich alpha-2-glycoprotein 1, lactate dehydrogenase, periodontal indicators, periodontal lesions, correlation

CLC Number:

R781.4

Tingting YANG,Yidan HUANG,Rongrong YANG,Ying YANG,Jing. ZHANG. Study on the relationship between serum LRG1， LDH with periodontal indexes and periodontal lesions in patients with type 2 diabetes and chronic periodontitis[J]. The Journal of Practical Medicine, 2024, 40(16): 2250-2255.

Figures/Tables 9

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References 26

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组别	CP组（n = 112）	T2DM组（n = 112）	T2DM合并CP组（n = 112）	F值	P值
男/女（例）	60/52	61/51	58/54	0.167	0.920
年龄（x ± s，岁）	51.20 ± 6.43	52.03 ± 6.51	52.14 ± 6.30	0.719	0.488
体质量指数（x ± s，kg/m²）	23.51 ± 4.52	23.57 ± 4.63	23.54 ± 4.67	0.005	0.995

病变程度	特征
0级	牙龈健康且无病变
1级	牙龈出现轻度炎症，有轻微变红并有水肿，探诊触及时无出血和渗出物，牙槽未松动，牙齿松动度为Ⅰ级
2级	牙龈出现明显炎症，探诊触及时易出血，还有少量渗出物，牙龈红肿还有小溃疡，牙颈部暴露，牙齿松动度达Ⅰ~Ⅱ级
3级	牙龈出现明显的炎症反应，牙槽骨吸收达到根尖1/3处，有自动性出血，溢脓，牙齿松动度Ⅱ~Ⅲ级

项目	CP组（n = 112）	T2DM组（n = 112）	T2DM合并CP组（n = 112）	F值	P值
TG（mmol/L）	1.42±0.32	1.89±0.43^a	2.03±0.51^ab	62.670	< 0.001
TC（mmol/L）	4.50±0.64	4.51±0.68	4.72±0.72^ab	3.730	0.025
LDL-C（mmol/L）	2.71±0.41	3.22±0.50^a	3.45±0.53^ab	68.946	< 0.001
HDL-C（mmol/L）	1.27±0.28	1.10±0.23^a	1.02±0.12^ab	37.590	< 0.001
FPG（mmol/L）	4.77±1.03	9.78±1.10^a	10.45±1.24^ab	850.056	< 0.001
AL（mm）	3.25±0.46	1.72±0.12^a	3.90±0.47^ab	941.787	< 0.001
PD（mm）	3.21±0.52	1.94±0.41^a	5.05±0.46^ab	1 263.734	< 0.001
BI	2.48±0.41	0.71±0.20^a	2.99±0.50^ab	1 050.248	< 0.001
PLI	1.32±0.28	1.34±0.27	1.39±0.29	1.856	0.158

组别	例数	LRG1（ng/mL）	LDH（U/L）
CP组	112	446.37 ± 19.57	228.64 ± 23.24
T2DM组	112	468.49 ± 20.46^a	236.64 ± 23.31^a
T2DM合并CP组	112	480.68 ± 25.24^ab	269.82 ± 25.16^ab
F值		70.652	93.330
P值		< 0.001	< 0.001

项目	轻度组（n = 50）	中度组（n = 41）	重度组（n = 21）	F值	P值
LRG1（ng/mL）	470.35 ± 24.35	486.39 ± 25.26^a	494.15 ± 27.34^ab	8.217	< 0.001
LDH（U/L）	257.26 ± 23.86	270.38 ± 25.67^a	298.64 ± 27.25^ab	19.987	< 0.001
AL（mm）	3.64 ± 0.43	3.98 ± 0.48^a	4.36 ± 0.52^ab	18.607	< 0.001
PD（mm）	4.51 ± 0.42	5.28 ± 0.49^a	5.86 ± 0.51^ab	70.942	< 0.001
BI	2.74 ± 0.48	3.01 ± 0.50^a	3.56 ± 0.56^ab	19.702	< 0.001
PLI	1.38 ± 0.25	1.39 ± 0.29^a	1.42 ± 0.37^ab	0.141	0.868

Study on the relationship between serum LRG1， LDH with periodontal indexes and periodontal lesions in patients with type 2 diabetes and chronic periodontitis

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项目	LRG1		LDH
项目	r值	P值	r值	P值
AL	0.501	< 0.001	0.519	< 0.001
PD	0.512	< 0.001	0.543	< 0.001
BI	0.508	< 0.001	0.521	< 0.001
LRG1	-	-	0.598	< 0.001
LDH	0.598	< 0.001	-	-

项目	β	SE	Wald χ²	P值	OR	95%CI
LRG1	1.150	0.236	23.756	0.001	3.158	1.989 ~ 5.012
LDH	1.168	0.304	14.757	< 0.001	3.215	1.772 ~ 5.834
AL	0.764	0.201	14.450	< 0.001	2.147	1.448 ~ 3.184
PD	1.672	0.598	7.814	0.005	5.321	1.648 ~ 17.180
BI	1.193	0.402	8.812	0.003	3.298	1.500 ~ 7.252

项目	AUC	95%CI	灵敏度（%）	特异度（%）	截断值
LRG1（ng/mL）	0.829	0.735 ~ 0.924	75.24	79.64	489.674
LDH（U/L）	0.806	0.696 ~ 0.916	78.54	80.34	286.351
联合诊断	0.910	0.834 ~ 0.986	96.24	78.24	-

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