血清Aβ1-42、P-Tau181和Hcy与帕金森病患者睡眠障碍的相关性

doi:10.3969/j.issn.1006-5725.2024.11.003

Abstract

Abstract:

Objective To investigate the correlations of serum Aβ1?42， P?Tau181， and Hcy levels with sleep disorders in patients with Parkinson's disease （PD）. Methods A total of 80 PD patients were divided into a normal sleep group （< 7 points） and a sleep disorder group （≥ 7 points） based on the evaluations with Pittsburgh Sleep Quality Index （PSQI）. Univariate and multivariate logistic regression analyses were performed to investigate the correlations between the levels of serum Aβ1-42， P-Tau181， and Hcy levels and sleep disorders. Receiver operating characteristic （ROC） curves were used to analyze the efficacy parameters of different indicators in predicting sleep disorders in those patients. Results Univariate and multivariate logistic regression analyses showed that serum Aβ1-42 and Hcy were protective and independent risk factors for sleep disorders in the PD patients， respectively （P < 0.05）. The predictive AUCs of serum Aβ1-42 and Hcy levels for sleep disorders in the PD patients were 0.757 （95% CI： 0.652 ~ 0.861） and 0.796 （95% CI： 0.688 ~ 0.905）， respectively. Conclusion The levels of serum Aβ1-42 and Hcy in PD patients are closely related to sleep disorders. Therefore， they can be used as predictive factors for clinical diagnosis of PD with sleep disorders.

Key words: Parkinson's disease, sleep disorder, Aβ1-42, P-Tau181, Hcy, correlation

CLC Number:

R742.5

Yanyun LI,Xueping CHEN,Peipei TIAN,Ting BAI,Qin GUO,Miao. GUO. The correlations of serum Aβ1⁃42， P⁃Tau181， and Hcy levels with sleep disorders in Parkinson′s disease patients[J]. The Journal of Practical Medicine, 2024, 40(11): 1483-1487.

Figures/Tables 6

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Fig. 1

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References 23

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症状	例数	发生率（%）
PDSS-1	32	69.57
PDSS-2	37	80.43
PDSS-3	33	71.74
PDSS-4	16	34.78
PDSS-5	17	36.96
PDSS-6	25	54.35
PDSS-7	8	17.39
PDSS-8	35	76.09
PDSS-9	7	15.22
PDSS-10	10	21.74
PDSS-11	15	32.61
PDSS-12	13	28.26
PDSS-13	10	21.74
PDSS-14	24	52.17
PDSS-15	28	60.87

项目	睡眠正常组（n = 34）	睡眠障碍组（n = 46）	t/χ²值	P值
年龄（x ± s，岁）	64.83 ± 8.93	66.75 ± 9.54	0.914	0.363
性别［例（%）］			0.023	0.879
男	22（64.71）	29（63.04）
女	12（35.29）	17（36.96）
体质量指数（x ± s，kg/m²）	23.28 ± 4.83	23.82 ± 5.21	0.473	0.638
PD病程（x ± s，年）	4.64 ± 2.12	5.32 ± 1.84	1.531	0.130
UPDRS-Ⅲ评分（x ± s，分）	24.32 ± 4.93	26.84 ± 4.59	2.352	0.021
LED（x ± s，mg/d）	458.73 ± 143.82	532.93 ± 183.65	1.953	0.054
HAMD评分（x ± s，分）	10.32 ± 2.91	11.08 ± 3.21	1.089	0.280
HAMA评分（x ± s，分）	10.49 ± 2.54	11.32 ± 2.86	1.345	0.183
H-Y分级［例（%）］			0.035	0.972
1期	2（5.88）	4（8.70）
2期	12（35.29）	15（32.80）
3期	10（29.41）	13（28.26）
4期	8（23.53）	11（23.91）
5期	2（5.88）	3（6.52）
文化程度［例（%）］			0.208	0.835
小学	4（11.76）	7（15.22）
初中	10（29.41）	13（28.26）
高中	12（35.29）	15（32.61）
大专及以上	8（23.53）	11（23.91）
Aβ1-42（x ± s，μg/L）	1.35 ± 0.59	0.97 ± 0.54	2.991	0.004
P-Tau181（x ± s，ng/L）	87.26 ± 16.83	90.34 ± 17.54	0.790	0.432
Hcy（x ± s，μmol/L）	21.41 ± 2.31	24.28 ± 2.79	4.885	< 0.001

因素	B值	SE值	Wald χ²值	P值	OR值	95%CI
血清Aβ1-42	-1.321	0.318	17.256	0.024	0.267	0.143 ~ 0.498
血清Hcy	2.614	0.452	33.445	< 0.001	13.654	5.630 ~ 33.113
UPDRS-Ⅲ评分	0.503	0.299	2.830	0.097	1.654	0.920 ~ 2.971

指标	AUC	SE值	95%CI	cut?off值	敏感度（%）	特异度（%）	约登指数（%）	阳性预测值（%）	阴性预测值（%）
Aβ1-42	0.757	0.053	0.652 ~ 0.861	≤ 0.935 μg/L	93.48	51.43	44.91	71.67	85.71
Hcy	0.796	0.055	0.688 ~ 0.905	≥ 22.875 μmol/L	86.96	76.47	63.43	83.33	81.25

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The correlations of serum Aβ1⁃42， P⁃Tau181， and Hcy levels with sleep disorders in Parkinson′s disease patients

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