Abstract:

Objective To explore the effects of liraglutide on gonadal hormone and sexual function in over⁃ weight or obese male patients with type 2 diabetes mellitus（T2DM）. Methods One hundred and twenty overweight or obese（BMI ≥ 24 kg/m2 ）male patients with T2DM were selected as the research subjects. They were randomly divided into experimental group treated with liraglutide combined with metformin（n = 60）and control group treated with insulin glargine combined with metformin（n = 60）. The changes of body weight，fasting blood glucose，2 h postprandial blood glucose，glycosylated hemoglobin，testosterone，SHBG and gonadal function before and after treatment were observed in a 12⁃week follow up. Results Fasting blood glucose，2 h postprandial blood glucose， glycosylated hemoglobin decreased significantly in both groups after treatment. Body weight and BMI of the experi⁃ mental group decreased significantly，while those of the control group had no significant change. The testosterone and gonadal function of the experimental group were slightly improved after treatment，but the difference had no statistical significance. Twenty⁃one patients lost weight ≥ 2.5 kg in the experimental group and the total testosterone and free testosterone were significantly increased；compared with patients with weight loss < 2.5 kg，the differences were statistically significant. Conclusion In the treatment of overweight or obese men with T2DM，liraglutide combined with Metformin can increase testosterone level in those who lost weight ≥ 2.5 kg.

Key words:

type 2 diabetes mellitus, obesity, liraglutide, testosterone