关键词:

食管癌, miR?27a, miR?138?5p, 生存, 预测, 复发, 转移

Abstract:

Objective To explore the predictive effect of mir⁃27a and mir⁃138⁃5p on postoperative survival of patients with esophageal cancer and their relationship with recurrence and metastasis. Methods From January 2014 to January 2017，300 suspected esophageal cancer patients according to the pathological examination results， were divided into esophageal cancer group（n = 70），and esophagitis group（n = 230），and 70 healthy physical examination patients were selected as health group. The expression level of miR⁃27a and miR⁃138⁃5p in serum of three groups was detected by fluorescence quantitative PCR. The correlation between the expression of serum mir⁃ 27a and mir⁃138⁃5p and postoperative recurrence and metastasis was analyzed，and the predictive value of serum mir⁃27a and mir⁃138⁃5p for postoperative survival of patients with esophageal cancer was evaluated. Results In all the three groups，the expression of serum mir ⁃ 27a mRNA was gradually down regulated，while mir ⁃ 138⁃5p mRNA up⁃regulated（P < 0.05）. Clinical stage，degree of radical resection and the relative expression of miR⁃27a and miR ⁃138⁃5p mRNA were independent factors influencing the recurrence and metastasis of esophageal cancer （P < 0.05）. Compared with the death group，the expression level of miR⁃27a mRNA in the survival group was lower， but that of miR⁃138⁃5p mRNA was higher（P < 0.05）. The AUC of serum miR⁃27a and miR⁃138⁃5p for predicting postoperative survival of esophageal cancer were 0.773，0.731 and 0.829，respectively. Conclusion MiR⁃27a and miR⁃138⁃5p have significant predictive value for postoperative survival of patients with esophageal cancer，and are correlated with postoperative recurrence and metastasis.

Key words: esophageal cancer,  , miR ?27a,  , miR ?138?5p,  , survival,  , predictive,  , recurrence,  , metastasis