Abstract:

Objective To investigate the distribution characteristics of Mycoplasma pneumoniae（MP）， Chlamydia pneumoniae（CP）and Legionella pneumophila（LP）in hospitalized children with acute respiratory in⁃ fection（ARTI）in Yuexue District，Guangzhou from 2012 to 2019. Methods A total of 34，440 ARTI hospital⁃ ized children from January 2012 to December 2019 were selected as research subjects. Whole blood and urine were collected. Serum MP was detected by passive agglutination method respectively. Serum CP was detected by ELISA. Urine LP was detected by immunochromatography. Results Among 34，440 hospitalized children with ARTI，the detection rates of MP，CP and LP were 8，882（25.79%），2，587（7.51%）and 1186（3.44%），respectively. The total MP detection rate was the highest（all P<0.05）. The total detection rates of the three pathogens in 2013， 2014 and 2019 were significantly higher than those in other years（all P<0.05）. The MP detection rate was the highest in each year（all P<0.05）. The three pathogens were detected all year round，with the highest total detec⁃ tion rate in Autumn and the lowest in Spring（all P<0.05）. The MP detection rate was the highest in each season （all P<0.05）. The total detection rate of three pathogens was the highest in the children with acute bronchopneumo⁃ nia and the lowest in those with acute laryngeal and tracheobronchitis（all P<0.05）. Among age groups，the overall detection rate of the three pathogens was the highest in the children aged 5-16 years. The MP detection rate was the lowest in the children aged 0-1 year（all P<0.05）. The detection rate of the same pathogen in the female chil⁃ dren was significantly higher than that in the male children（P<0.05）. The combined infections with MP+CP was the most common among the three pathogens（all P<0.001）. Conclusion MP，CP and LP are important patho⁃ gens that cause ARTI in children in this region，common，with its epidemic peaks probably in 2013 and 2019.

Key words:

acute respiratory tract infection, children, Mycoplasma pneumonia, Chlamydia pneu? monia, Legionella pneumophila